GLRB and GPHN

Number of citations of the paper that reports this interaction (PubMedID 7546736)
0

Data Source:
HPRD (in vivo, in vitro)

		GLRB	GPHN
Description		glycine receptor beta	gephyrin
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Glycine-gated Chloride Channel Complex Dendrite Chloride Channel Complex Cell Projection Synapse Postsynaptic Membrane Glycinergic Synapse GABA-ergic Synapse Postsynaptic Specialization	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Inhibitory Synapse Synaptic Membrane Glycinergic Synapse Postsynapse GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component Postsynaptic Specialization
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Glycine Binding Extracellularly Glycine-gated Ion Channel Activity Extracellularly Glycine-gated Chloride Channel Activity Protein-containing Complex Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding Catalytic Activity Signaling Receptor Binding Protein Binding ATP Binding Nitrate Reductase Activity Transferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Molybdopterin Cofactor Binding Metal Ion Binding Molecular Adaptor Activity Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity
	Biological Process	Startle Response Monoatomic Ion Transport Chloride Transport Neuropeptide Signaling Pathway Chemical Synaptic Transmission Acrosome Reaction Nervous System Development Visual Perception Adult Walking Behavior Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Synaptic Transmission, Glycinergic Righting Reflex Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Gamma-aminobutyric Acid Receptor Clustering Chloride Transmembrane Transport	Mo-molybdopterin Cofactor Biosynthetic Process Synapse Assembly Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdopterin Cofactor Biosynthetic Process Establishment Of Protein Localization Synapse Organization Synaptic Transmission, GABAergic Glycine Receptor Clustering Protein Localization To Membrane Gamma-aminobutyric Acid Receptor Clustering Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission	Molybdenum cofactor biosynthesis
Drugs		Glycine Lindane Memantine Seletracetam Cannabidiol Medical Cannabis Nabiximols	Formic acid Imidazole Propanoic acid
Diseases		Hyperekplexia	Hyperekplexia
GWAS		Cognitive decline (age-related) ( 28078323) Triglyceride levels x loop diuretics use interaction ( 31806883)	Appendicular lean mass ( 33097823) Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		2 interacting genes: APP GPHN	15 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MITD1 MTOR PFN1 PIN1 PSMA1 SPATS1 TUBA4A
Entrez ID		2743	10243
HPRD ID		11751	04893
Ensembl ID		ENSG00000109738	ENSG00000171723
Uniprot IDs		P48167	Q9NQX3
PDB IDs		5BKF 5BKG 7KUY 7L31 8DN2 8DN3 8DN4 8DN5	1JLJ
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Signaling Receptor Binding Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Postsynapse Response To Metal Ion Trans-synaptic Signaling Intermediate-density Lipoprotein Particle Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Synaptic Signaling Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Synapse Organization Glycine Receptor Clustering Postsynaptic Specialization, Intracellular Component Molybdopterin Cofactor Binding Nitrate Reductase Activity Molybdopterin Cofactor Biosynthetic Process Molybdopterin Adenylyltransferase Activity Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Molybdopterin Molybdotransferase Activity Gamma-aminobutyric Acid Receptor Clustering Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity	GABA-ergic Synapse Microtubule Associated Complex Protein-containing Complex Binding Postsynaptic Specialization Cytoskeleton Organization Microtubule Cytoplasmic Dynein Complex Regulation Of Protein Stability Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Phosphoprotein Binding Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Glycine-gated Chloride Channel Complex Extracellularly Glycine-gated Ion Channel Activity Cis-trans Isomerase Activity Microtubule-based Process Ciliary Tip Dynein Intermediate Chain Binding Dynein Complex Grb2-Sos Complex Myosin V Complex Protein Domain Specific Binding Cytoskeleton Cytosol Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Microtubule Cytoskeleton
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