APOBEC3C and MYO10

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		APOBEC3C	MYO10
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 3C	myosin X
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm	Ruffle Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Myosin Complex Lamellipodium Filopodium Filopodium Membrane Filopodium Tip Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cytoskeletal Protein Binding Spectrin Binding Protein-containing Complex Binding Actin Filament Binding Plus-end Directed Microfilament Motor Activity
	Biological Process	Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination Defense Response To Symbiont	Signal Transduction Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Regulation Of Filopodium Assembly
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	Regulation of actin dynamics for phagocytic cup formation Netrin-1 signaling FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Body mass index (change over time) in lung cancer or chronic obstructive pulmonary disease ( 28044437) Circulating odd-numbered chain saturated fatty acid levels (C17:0) ( 29738550) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Normal facial asymmetry (deformation magnitude) ( 30631343) Obesity-related traits ( 23251661) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Polycystic ovary syndrome (adjusted for age) ( 34791234) Response to antidepressants (symptom remission) ( 29160301) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		30 interacting genes: ARIH2 CHTOP CUL5 FBXO7 HHEX HNRNPK MYO10 NXF1 PCBP2 PCBP3 PRPF31 PRR3 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J SF1 SHBG SNRPA SNW1 SRPK2 TRAF3 TRIB3 UBC UNKL ZNF250 ZNF408 ZNF48 ZNF581	10 interacting genes: ACTA1 APOBEC3C CALM1 CALML3 DYNLL1 EIF4ENIF1 ITGB5 PELI2 PLA2G10 RAPH1
Entrez ID		27350	4651
HPRD ID		09671	03283
Ensembl ID		ENSG00000244509	ENSG00000145555
Uniprot IDs		Q9NRW3	B7Z3D4 Q9HD67
PDB IDs		3VM8 3VOW	2LW9 3AU4 3AU5 3PZD 5I0H 5I0I 5KG8
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding RNA Splicing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding MRNA Processing Nucleus Positive Regulation Of RNA Splicing RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Metabolic Process Identical Protein Binding Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Viral RNA Genome Replication Nucleobase-containing Compound Metabolic Process Transcription Export Complex Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Cul5-RING Ubiquitin Ligase Complex Negative Regulation Of CGAS/STING Signaling Pathway Protein Binding Regulation Of Gene Expression Catalytic Step 2 Spliceosome Viral Genome Replication Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Protein K48-linked Ubiquitination Nuclear Speck Ubiquitin Ligase Complex Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process CGAS/STING Signaling Pathway Ubiquitin-protein Transferase Activity Nucleolus 14-3-3 Protein Binding	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Detection Of Calcium Ion Calcineurin-mediated Signaling Myelin Sheath Dynein Intermediate Chain Binding Dynein Complex Substantia Nigra Development Filopodium Cytoskeleton Sarcomere Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Integrin Alphav-beta5 Complex Platelet Activating Factor Catabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
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