GLS2 and PDE2A

		GLS2	PDE2A
Description		glutaminase 2	phosphodiesterase 2A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Glutaminase Activity Protein Binding Hydrolase Activity	Nucleotide Binding Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Metabolic Process L-glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CGMP-mediated Signaling Monocyte Differentiation Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	cGMP effects G alpha (s) signalling events
Drugs		Glutamic acid	Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases
GWAS		Adverse response to drug ( 30420678) Axial length ( 24144296) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Lipoprotein (a) levels ( 33730874) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 23093944 31636271) Serum metabolite levels (CMS) ( 31636271)	Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)
Interacting Genes		14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR PAG1 PATJ RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1	1 interacting genes: ITSN1
Entrez ID		27165	5138
HPRD ID		05901	04041
Ensembl ID		ENSG00000135423	ENSG00000186642
Uniprot IDs		A0A087X004 Q9UI32	O00408 Q8IW54
PDB IDs		4BQM 5U0K 8SZL 8T0Z	1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Ionotropic Glutamate Receptor Binding GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering GDP Metabolic Process Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Synaptic Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Localization To Cell Junction Kinase Binding GMP Metabolic Process Postsynaptic Density Membrane Adherens Junction Cell Junction Nucleoside Monophosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Juxtaparanode Region Of Axon Nucleoside Diphosphate Metabolic Process Basolateral Plasma Membrane Plasma Membrane Cellular Response To Potassium Ion Localization Within Membrane Purine Ribonucleotide Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Protein Localization To Membrane Chemical Synaptic Transmission Response To Potassium Ion Bicellular Tight Junction Neuron Projection Trans-synaptic Signaling Synaptic Signaling Purine Nucleotide Metabolic Process AMPA Glutamate Receptor Complex Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Nucleotide Metabolic Process Regulation Of Sodium Ion Transmembrane Transport Intracellular Signal Transduction Protein Kinase Binding Purine-containing Compound Metabolic Process Cell-cell Junction Cell Adhesion P2Y1 Nucleotide Receptor Binding Hydroxypyruvate Reductase [NAD(P)H] Activity	Positive Regulation Of Base-excision Repair Regulation Of Base-excision Repair Regulation Of Mitotic Nuclear Division Apoptotic Process Involved In Development Regulation Of Nuclear Division Endocytosis Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Regulation Of DNA Repair Neural Crest Cell Migration Involved In Heart Formation Response To TNF Agonist Oxidized Pyrimidine DNA Binding Brexanolone Catabolic Process Stereocilium Shaft
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