INVS and TMEM245

		INVS	TMEM245
Description		inversin	transmembrane protein 245
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytoskeleton Microtubule Cilium Membrane Cell Projection	Membrane
	Molecular Function	Protein Binding Calmodulin Binding
	Biological Process	Kidney Development Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Protein Localization To Ciliary Inversin Compartment
Pathways
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Macular thickness ( 30535121) Preeclampsia ( 23551011)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Menarche (age at onset) ( 25231870) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		4 interacting genes: CALM2 HIF1AN NPHP1 ZNF512B
Entrez ID		27130	23731
HPRD ID		08356	09866
Ensembl ID		ENSG00000119509	ENSG00000106771
Uniprot IDs		Q2M1I4 Q9Y283	H7C0G1 Q9H330
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Apolipoprotein A-I-mediated Signaling Pathway Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Lipoprotein Biosynthetic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Phosphatidylcholine Floppase Activity Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization Involved In Establishment Of Planar Polarity [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Peptidyl-histidine Dioxygenase Activity Oxygen Sensor Activity Positive Regulation Of Sequestering Of Calcium Ion Ankyrin Repeat Binding Carboxylic Acid Binding High-density Lipoprotein Particle Assembly Phospholipid Efflux High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction ATPase-coupled Intramembrane Lipid Transporter Activity Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Titin Binding Adenylate Cyclase Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Bicellular Tight Junction Assembly Spermatid Differentiation Positive Regulation Of Vasculogenesis	Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Localization To Ciliary Inversin Compartment Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Chaperone Complex Negative Regulation Of Cellular Response To Hypoxia Adenyl-nucleotide Exchange Factor Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Regulation Of Cellular Response To Hypoxia Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Response To Ischemia Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Signaling Protein Localization To Cilium
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