NOXO1 and NOXA1

Number of citations of the paper that reports this interaction (PubMedID 39426288)
35

Data Source:
BioGRID (proximity labelling technology)
HPRD (two hybrid, in vivo)

		NOXO1	NOXA1
Description		NADPH oxidase organizer 1	NADPH oxidase activator 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane NADPH Oxidase Complex	Cytoplasm Cytosol Plasma Membrane Membrane NADPH Oxidase Complex
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Enzyme Binding Phosphatidylinositol Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Extracellular Matrix Disassembly Superoxide Anion Generation Regulation Of Respiratory Burst	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Respiratory Burst
Pathways		RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Ecabet
Diseases
GWAS		Red cell distribution width ( 32888494)	Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		2 interacting genes: NOX1 NOXA1	57 interacting genes: ACTMAP ANKRD55 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 SPMIP6 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620
Entrez ID		124056	10811
HPRD ID		14834	17644
Ensembl ID		ENSG00000196408	ENSG00000188747
Uniprot IDs		A8K832 Q8NFA2	Q86UR1
PDB IDs		2L73	7CFZ
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Small GTPase Binding Oxygen Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Superoxide-generating NADPH Oxidase Activity Cellular Response To Hyperoxia Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NAD(P)H Oxidase Activity NAD(P)H Oxidase H2O2-forming Activity Cellular Response To Increased Oxygen Levels Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Response To Hyperoxia Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Respiratory Burst Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vascular Endothelial Growth Factor Production Hydrogen Peroxide Metabolic Process NADP+ Metabolic Process NADP Binding Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway JNK Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of JNK Cascade SH3 Domain Binding Nicotinamide Nucleotide Metabolic Process	NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Regulation Of Respiratory Burst Respiratory Burst Regulation Of Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Manchette Benzodiazepine Receptor Binding Erythrocyte Enucleation Protein Binding Intermediate Filament Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Cytokine Production Superoxide-generating NADPH Oxidase Activator Activity Intracellular Signaling Cassette Internal Protein Amino Acid Acetylation Negative Regulation Of Glial Cell Apoptotic Process Thioesterase Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?