GIPR and GIP

Number of citations of the paper that reports this interaction (PMID 8795084)
6

Data Source:
HPRD (in vivo)

		GIPR	GIP
Gene Name		gastric inhibitory polypeptide receptor	gastric inhibitory polypeptide
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen Neuronal Cell Body
	Molecular Function	Transmembrane Signaling Receptor Activity Gastric Inhibitory Peptide Receptor Activity Peptide Hormone Binding	Hormone Activity
	Biological Process	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Glucose Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Gastric Inhibitory Peptide Signaling Pathway Response To Axon Injury Response To Calcium Ion Response To Fatty Acid	Signal Transduction Female Pregnancy Memory Adult Locomotory Behavior Response To Glucose Response To Selenium Ion Positive Regulation Of Glucose Transport Response To Organic Cyclic Compound Sensory Perception Of Pain Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Response To Lipid Exploration Behavior Response To Drug Response To Starvation Response To Amino Acid Response To Peptide Hormone Positive Regulation Of CAMP-mediated Signaling Cellular Protein Metabolic Process Response To Axon Injury Regulation Of Insulin Secretion Digestive System Development Long-term Synaptic Potentiation Positive Regulation Of Glucagon Secretion Triglyceride Homeostasis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR G alpha (s) signalling events Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Glucagon-type ligand receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes Peptide hormone metabolism GPCR downstream signaling Class B/2 (Secretin family receptors) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		Body mass index ( 22344219 22344221 20935630) Obesity ( 23563607) Subcutaneous adipose tissue ( 22589738) Two-hour glucose challenge ( 20081857)	Coronary heart disease ( 21378990)
Protein-Protein Interactions		2 interactors: GIP LNX1	5 interactors: ADAMTSL4 GIPR KRTAP10-3 NOTCH2NL SGTA
Entrez ID		2696	2695
HPRD ID		00670	15925
Ensembl ID		ENSG00000010310	ENSG00000159224
Uniprot IDs		B7WP14 P48546	P09681
PDB IDs		2QKH 4HJ0	1T5Q 2B4N 2L70 2L71 2OBU 2QKH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glucagon Secretion Response To Selenium Ion Regulation Of Glucagon Secretion Positive Regulation Of CAMP-mediated Signaling Regulation Of CAMP-mediated Signaling Exploration Behavior Triglyceride Homeostasis Acylglycerol Homeostasis	Gastric Inhibitory Peptide Signaling Pathway
Tagcloud ?		3t3 adipocyte adipocytes antiapoptosis attributable biology car chemokines circulating consequence cytokines exerts ikb ikkbeta impaired insulinotropic jnk jun knockout l1 obese obesity overexpressed pka rising secretion stimulated uptake	32pua aspirated aspiration corp curved cystadenomas cytologic eum eus fg gauge grassau medizin melville negatives ny olympus orangeburg passes pentax pseudocyst resolving rtfna rtfnas staging suspicious technik tomographic unsuccessful
Tagcloud (Difference) ?		3t3 adipocyte adipocytes antiapoptosis attributable biology car chemokines circulating consequence cytokines exerts ikb ikkbeta impaired insulinotropic jnk jun knockout l1 obese obesity overexpressed pka rising secretion stimulated uptake	32pua aspirated aspiration corp curved cystadenomas cytologic eum eus fg gauge grassau medizin melville negatives ny olympus orangeburg passes pentax pseudocyst resolving rtfna rtfnas staging suspicious technik tomographic unsuccessful
Tagcloud (Intersection) ?