GIPR and GIP

Number of citations of the paper that reports this interaction (PubMedID 17715056)
52

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vivo)

		GIPR	GIP
Description		gastric inhibitory polypeptide receptor	gastric inhibitory polypeptide
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Gastric Inhibitory Peptide Receptor Activity Peptide Hormone Binding Glucagon Family Peptide Binding	Hormone Activity Protein Binding Gastric Inhibitory Polypeptide Receptor Binding Glucagon Receptor Binding Receptor Ligand Activity
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Generation Of Precursor Metabolites And Energy Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Glucose Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Gastric Inhibitory Peptide Signaling Pathway Response To Axon Injury Regulation Of Insulin Secretion Response To Calcium Ion Response To Fatty Acid	Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Memory Adult Locomotory Behavior Response To Glucose Sensory Perception Of Pain Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Exploration Behavior Gastric Inhibitory Peptide Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Response To Starvation Regulation Of Insulin Secretion
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Tirzepatide
Diseases
GWAS		Adult body size ( 32376654) Blood urea nitrogen levels ( 29403010 31152163) Body mass index ( 29273807 29381148 28892062 28448500 24861553 31453325 22344219 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Breast cancer ( 29059683) Femur bone mineral density x serum urate levels interaction ( 34046847) Fruit consumption ( 32066663) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) GIP levels in response to oral glucose tolerance test (fasting) ( 29093273) Glycated hemoglobin levels ( 34059833) Hemoglobin A1c levels ( 29403010) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Left ventricular end-diastolic volume (MTAG) ( 33495596) Left ventricular end-systolic volume (MTAG) ( 33495596) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Obesity ( 23563607) Pancreatic beta-cell glucose sensitivity ( 32944759) Pulse pressure ( 30224653) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 30578418) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 30718926 30297969 32499647 30054458 29358691 28869590 26818947 24509480 22885922) Type 2 diabetes (adjusted for BMI) ( 29632382) Urinary potassium to creatinine ratio ( 30910378) Waist circumference ( 31453325) Waist circumference variance ( 31453325)	Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) Blood glucose levels ( 31928498) Coronary artery disease ( 29212778) Coronary heart disease ( 21378990) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Liver enzyme levels (alkaline phosphatase) ( 33972514) Systolic blood pressure ( 30578418 31928498) Type 2 diabetes ( 28566273 29358691) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: GIP LNX1	6 interacting genes: ADAMTSL4 GIPR KRTAP10-3 NOTCH2NLA SGTA SGTB
Entrez ID		2696	2695
HPRD ID		00670	15925
Ensembl ID		ENSG00000010310	ENSG00000159224
Uniprot IDs		K7EPD9 P48546	P09681
PDB IDs		2QKH 4HJ0 6DKJ 7DTY 7FIN 7FIY 7RA3 7RBT 7VAB 8ITL 8ITM 8WA3 8YW4	1T5Q 2B4N 2L70 2L71 2OBU 2QKH 7DTY 7RA3
Enriched GO Terms of Interacting Partners?		Glucagon Receptor Binding Gastric Inhibitory Polypeptide Receptor Binding Gastric Inhibitory Peptide Signaling Pathway Endocrine Pancreas Development Synapse Maturation	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Glucagon Family Peptide Binding Gastric Inhibitory Peptide Receptor Activity Protein Targeting To Membrane Pigment Cell Development Gastric Inhibitory Peptide Signaling Pathway Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Establishment Of Protein Localization To Membrane Protein Targeting BAT3 Complex Binding Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Interstitial Matrix
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