GHRH and GHRHR

Number of citations of the paper that reports this interaction (PMID 1333056)
27

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		GHRH	GHRHR
Gene Name		growth hormone releasing hormone	growth hormone releasing hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Terminal Bouton	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Matrix Secretory Granule
	Molecular Function	Growth Hormone-releasing Hormone Activity Growth Hormone-releasing Hormone Receptor Binding	G-protein Coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding
	Biological Process	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation CAMP-mediated Signaling Adenohypophysis Development Growth Hormone Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Food Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Secretion	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Lactation Positive Regulation Of Cell Proliferation Determination Of Adult Lifespan CAMP-mediated Signaling Water Homeostasis Growth Hormone Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Cell Maturation Multicellular Organismal Reproductive Process Regulation Of Protein Metabolic Process Response To Glucocorticoid Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Sermorelin Tesamorelin
Diseases
GWAS
Protein-Protein Interactions		1 interactors: GHRHR	3 interactors: GHRH GHRL MLNR
Entrez ID		2691	2692
HPRD ID		11752	00748
Ensembl ID		ENSG00000118702	ENSG00000106128
Uniprot IDs		P01286	Q02643
PDB IDs			2XDG
Enriched GO Terms of Interacting Partners?		Somatotropin Secreting Cell Development Somatotropin Secreting Cell Differentiation Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Adenohypophysis Development Determination Of Adult Lifespan CAMP-mediated Signaling Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Positive Regulation Of Adenylate Cyclase Activity Multicellular Organismal Aging Positive Regulation Of Lyase Activity Positive Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Pituitary Gland Development Regulation Of Adenylate Cyclase Activity Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Lactation Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Peptide Hormone Secretion Peptide Secretion Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Cyclic Nucleotide Metabolic Process Hormone Secretion Regulation Of CAMP Biosynthetic Process Diencephalon Development Hormone Transport Peptide Transport Regulation Of Multicellular Organism Growth Regulation Of CAMP Metabolic Process Positive Regulation Of Hormone Secretion Body Fluid Secretion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Amide Transport Second-messenger-mediated Signaling Cell Maturation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Developmental Growth Response To Glucocorticoid Response To Corticosteroid Mammary Gland Development Hormone Metabolic Process Response To Estrogen	Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Positive Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Regulation Of Circadian Rhythm Regulation Of Multicellular Organism Growth Positive Regulation Of Hormone Secretion Digestion Positive Regulation Of Behavior Amide Transport G-protein Coupled Receptor Signaling Pathway Cortisol Secretion Positive Regulation Of Developmental Growth Regulation Of Behavior Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Peptide Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Hormone Secretion Regulation Of Hormone Levels Regulation Of Developmental Growth Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Positive Regulation Of Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Response To Nutrient Levels Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Response To Extracellular Stimulus Gastric Acid Secretion Secretion By Cell Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Adenohypophysis Development
Tagcloud ?		acth anticholinergic blockade cortisol diphenhydramine dph h1 hex hexapeptide hexarelin histamine histaminergic man micrograms min modify persisted pg prl releases releasing rise sem somatotrope stimulatory terfenadine trf yr	abeta appswe autosomal dark deprivation diurnal fluctuation interstitial intracerebroventricular intraperitoneal isf lit manipulating microdialysis neurofibrillary orexin overexpress possibilities ps1app ps1deltae9 psen1 releasing sleep substance tangles wake wakefulness
Tagcloud (Difference) ?		acth anticholinergic blockade cortisol diphenhydramine dph h1 hex hexapeptide hexarelin histamine histaminergic man micrograms min modify persisted pg prl releases rise sem somatotrope stimulatory terfenadine trf yr	abeta appswe autosomal dark deprivation diurnal fluctuation interstitial intracerebroventricular intraperitoneal isf lit manipulating microdialysis neurofibrillary orexin overexpress possibilities ps1app ps1deltae9 psen1 sleep substance tangles wake wakefulness
Tagcloud (Intersection) ?		releasing