STEAP1 and PSMD2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		STEAP1	PSMD2
Description		STEAP family member 1	proteasome 26S subunit ubiquitin receptor, non-ATPase 2
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GO Annotations	Cellular Component	Endosome Plasma Membrane Cell-cell Junction Endosome Membrane Membrane	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Proteasome Storage Granule Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Heme Binding Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity	Protein Binding Enzyme Regulator Activity
	Biological Process		Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Type 2 diabetes ( 32499647)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body mass index ( 29273807)
Interacting Genes		1 interacting genes: PSMD2	31 interacting genes: ADRM1 BAG1 CALM1 CCT2 DSCAM DSCR9 FAF2 FKBP8 LINC01554 LRIF1 MTNR1A NDRG1 NUB1 PSMB4 PSMC1 PSMC2 PSMD5 PTN STEAP1 STUB1 TBC1D3B TBC1D3G TNFRSF1A UBD UBE3C UBLCP1 UNC119 USP14 VPS9D1 ZBTB16 ZBTB39
Entrez ID		26872	5708
HPRD ID		05106	05870
Ensembl ID		ENSG00000164647	ENSG00000175166
Uniprot IDs		Q9UHE8	Q13200
PDB IDs		6Y9B 8UCD	5GJQ 5GJR 5L4K 5LN3 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7UIH 7UJD 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Fusion To Target Membrane Proteasome Storage Granule Neurotransmitter Receptor Transport Trans-Golgi Network Transport Vesicle Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Endosome To Plasma Membrane Protein Transport Myosin V Binding Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Proteasome Accessory Complex Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Non-motile Cilium Regulation Of Long-term Neuronal Synaptic Plasticity Enzyme Regulator Activity Vesicle Docking Involved In Exocytosis Protein Tyrosine Kinase Binding Ciliary Base Regulation Of Neuronal Synaptic Plasticity Protein Localization To Synapse Receptor Localization To Synapse Protein Localization To Cilium Ciliary Membrane Establishment Of Protein Localization To Plasma Membrane Vesicle Docking Proteasome Complex Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels GDP Binding Protein Localization To Cell Junction Endocytic Recycling Phagocytic Vesicle Phagocytic Vesicle Membrane Organelle Localization By Membrane Tethering Membrane Docking Vesicle-mediated Transport In Synapse Cellular Response To Insulin Stimulus Vesicle Fusion Recycling Endosome Membrane	Proteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Proteasomal Protein Catabolic Process Proteasome Accessory Complex Proteasome Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteasome-activating Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Assembly Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Type II Interferon Regulation Of ERAD Pathway Presynaptic Cytosol
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