GCH1 and CHMP4A

		GCH1	CHMP4A
Description		GTP cyclohydrolase 1	charged multivesicular body protein 4A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Autophagosome Membrane Kinetochore ESCRT III Complex Nucleus Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat Midbody Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Amphisome Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity GTPase Activity GTP Cyclohydrolase I Activity Protein Binding GTP Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Mitogen-activated Protein Kinase Binding	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity ATPase Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Type II Interferon Response To Tumor Necrosis Factor Dopamine Biosynthetic Process Pteridine-containing Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals	Plasma Membrane Repair Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Protein Transport Macroautophagy Nuclear Membrane Reassembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Nervous System Process Protein Polymerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Plasma Membrane Tubulation Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs		Guanine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ	14 interacting genes: CC2D1A CDK13 CHMP3 CHMP4B CHMP4C CHMP5 CHMP6 NTAQ1 NUTF2 PDCD6IP STAMBP SYT17 TTC19 VPS4A
Entrez ID		2643	29082
HPRD ID		02573	16597
Ensembl ID		ENSG00000131979	ENSG00000254505
Uniprot IDs		P30793 Q8IZH9	Q9BY43
PDB IDs		1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89 7ALA 7ALB 7ALC 7ALQ	3C3O 5MK1
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell GMP Binding Regulation Of Protein Stability Establishment Of Protein Localization Cellular Localization Extrinsic Component Of Synaptic Vesicle Membrane Protein Targeting Protein Kinase Binding ATPase Activator Activity Intracellular Protein Localization MHC Class II Protein Complex Binding Protein Transport Melanosome Protein-folding Chaperone Binding Unfolded Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity Import Into Nucleus Intracellular Protein Transport Protein Folding Chaperone Complex Intracellular Transport GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Establishment Of Protein Localization To Organelle Exocrine System Development Type 1 Cannabinoid Receptor Binding ATP Metabolic Process Hsp90 Protein Binding	Viral Budding Via Host ESCRT Complex Midbody Abscission Viral Budding Mitotic Cytokinetic Process Multivesicular Body Assembly Viral Budding From Plasma Membrane Multivesicular Body Organization Endosome Organization Cytokinetic Process Mitotic Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Regulation Of Mitotic Spindle Assembly Metaphase Chromosome Alignment Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Regulation Of Spindle Assembly Multivesicular Body-lysosome Fusion Chromosome Localization Nuclear Pore Late Endosome To Vacuole Transport Lysosomal Membrane Organization Nucleus Organization Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Kinetochore Microtubule Membrane Assembly Viral Process Multivesicular Body Membrane Vesicle Organization Vesicle Budding From Membrane Midbody Vesicle Fusion Organelle Membrane Fusion Multivesicular Body Regulation Of Centrosome Duplication Plasma Membrane Organization Lysosomal Transport Autophagosome Membrane Organelle Fusion Regulation Of Centrosome Cycle
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