GBP3 and LRRC8B

		GBP3	LRRC8B
Description		guanylate binding protein 3	leucine rich repeat containing 8 VRAC subunit B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Immune System Process Defense Response To Bacterium Innate Immune Response Defense Response To Virus Cytolysis In Another Organism Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Pyroptotic Inflammatory Response	Monoatomic Ion Transport Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane
Pathways		Interferon gamma signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Miscellaneous transport and binding events
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Carotid intima media thickness ( 26343869) Femur bone mineral density x serum urate levels interaction ( 34046847)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)
Interacting Genes		1 interacting genes: MAP4K4
Entrez ID		2635	23507
HPRD ID		02683	18145
Ensembl ID		ENSG00000117226	ENSG00000197147
Uniprot IDs		Q9H0R5	A0A384N5V6 Q6P9F7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ARF Protein Signal Transduction Positive Regulation Of Keratinocyte Migration Creatine Kinase Activity Positive Regulation Of Focal Adhesion Disassembly MAP Kinase Kinase Kinase Kinase Activity Volume-sensitive Anion Channel Activity Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Cyclic Nucleotide Transport Guanine Nucleotide Transmembrane Transport Aspartate Transmembrane Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Hippo Signaling C4-dicarboxylate Transport Nucleotide Transmembrane Transport Hippo Signaling Positive Regulation Of Focal Adhesion Assembly Purine-containing Compound Transmembrane Transport Purine Nucleotide Transport Adenine Nucleotide Transport Nucleotide Transport Negative Regulation Of Cell-matrix Adhesion Regulation Of Hippo Signaling Positive Regulation Of Epithelial Cell Migration Regulation Of Cell-substrate Junction Organization Positive Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Epithelial Cell Migration Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Small GTPase Mediated Signal Transduction Carbohydrate Derivative Transport Dicarboxylic Acid Transport Amino Acid Transmembrane Transport Positive Regulation Of Cell Junction Assembly Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Amino Acid Transport Organic Acid Transmembrane Transport Monoatomic Ion Channel Complex Carboxylic Acid Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Organophosphate Ester Transport Regulation Of JNK Cascade Import Across Plasma Membrane	Positive Regulation Of Pyroptotic Inflammatory Response Cytolysis In Another Organism Cytolysis Cellular Response To Interleukin-1 Cellular Response To Type II Interferon Response To Interleukin-1 Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Killing Of Cells Of Another Organism Cellular Response To Lipopolysaccharide Positive Regulation Of Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide GTPase Activity Defense Response To Bacterium Defense Response To Virus Taurine Transmembrane Transport Volume-sensitive Anion Channel Activity Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane Response To Molecule Of Bacterial Origin GTP Binding Guanine Nucleotide Transmembrane Transport Response To Virus Cyclic Nucleotide Transport Response To Bacterium Cellular Response To Cytokine Stimulus Regulation Of Inflammatory Response Protein Hexamerization Positive Regulation Of Defense Response Cellular Response To Lipid Response To Cytokine Aspartate Transmembrane Transport Response To Peptide Nucleotide Transmembrane Transport Innate Immune Response Golgi Membrane C4-dicarboxylate Transport Perinuclear Region Of Cytoplasm Protein Homodimerization Activity Defense Response To Protozoan Defense Response To Other Organism Response To Protozoan Molecular Function Inhibitor Activity Defense Response To Symbiont Purine Nucleotide Transport Adenine Nucleotide Transport Purine-containing Compound Transmembrane Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?