GATM and CYP2E1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GATM	CYP2E1
Description		glycine amidinotransferase	cytochrome P450 family 2 subfamily E member 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Amidinotransferase Activity Glycine Amidinotransferase Activity Transferase Activity	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Metal Ion Binding Hsp90 Protein Binding Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Learning Or Memory Muscle Atrophy Positive Regulation Of Cold-induced Thermogenesis	Long-chain Fatty Acid Metabolic Process Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Monoterpenoid Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Halogenated Hydrocarbon Metabolic Process Long-chain Fatty Acid Biosynthetic Process
Pathways		Creatine metabolism	Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs Aspirin ADME Paracetamol ADME
Drugs		Ornithine Glycine Delta-Amino Valeric Acid gamma-Aminobutyric acid Norvaline Alpha-Aminobutyric Acid	Diacerein
Diseases		Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS		Chronic kidney disease ( 20383146 31152163 26831199) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 30604766 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Homoarginine levels ( 24047826) Phosphatidylcholine-ether levels ( 31551469) Renal function and chronic kidney disease ( 19430482) Serum metabolite levels ( 24625756 33031748) Urinary albumin-to-creatinine ratio ( 31511532) Urinary potassium to creatinine ratio ( 30910378)	Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		2 interacting genes: CYP2E1 LCOR	15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1
Entrez ID		2628	1571
HPRD ID		03838	11813
Ensembl ID		ENSG00000171766	ENSG00000130649
Uniprot IDs		A0A140VK19 P50440	P05181
PDB IDs		1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW 9JDW	3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?		Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Long-chain Fatty Acid Metabolic Process Benzene Metabolic Process Lipid Hydroxylation Long-chain Fatty Acid Omega-1 Hydroxylase Activity Monoterpenoid Metabolic Process Fatty Acid Metabolic Process Enzyme Binding Arachidonate Epoxygenase Activity Monocarboxylic Acid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Arachidonate-CoA Ligase Activity Lipid Biosynthetic Process Epoxygenase P450 Pathway Long-chain Fatty Acid-CoA Ligase Activity Histone Methyltransferase Binding Long-chain Fatty-acyl-CoA Biosynthetic Process Ubiquitin-specific Protease Binding Benzene-containing Compound Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Hsp90 Protein Binding Arachidonate Metabolic Process Very Long-chain Fatty Acid Metabolic Process Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Neuroblast Proliferation Hsp70 Protein Binding Transcription Corepressor Binding Fatty Acid Derivative Biosynthetic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Lipid Metabolic Process Endoplasmic Reticulum Membrane Monooxygenase Activity Peroxisomal Membrane Fatty Acid Derivative Metabolic Process Phenol-containing Compound Metabolic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neural Precursor Cell Proliferation Icosanoid Metabolic Process	Protein-folding Chaperone Binding Ubiquitin-ubiquitin Ligase Activity Response To Misfolded Protein Reverse Cholesterol Transport Misfolded Protein Binding Intracellular Membrane-bounded Organelle Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Tau Protein Binding Regulation Of Neuronal Signal Transduction Monocarboxylic Acid Metabolic Process 3-hydroxypropionyl-CoA Dehydratase Activity Modified Amino Acid Metabolic Process Glycine Amidinotransferase Activity Amidinotransferase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Regulation Of Hormone Metabolic Process Nitrate Catabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Formation Of Translation Preinitiation Complex Beta-alanine:pyruvate Transaminase Activity N(omega),N(omega)-dimethyl-L-arginine Catabolic Process (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity L-alanine Catabolic Process, By Transamination Regulation Of Cellular Response To Stress Protein Polyubiquitination Endoplasmic Reticulum Learning Or Memory Endoplasmic Reticulum Unfolded Protein Response Protein Autoubiquitination Regulation Of Multicellular Organismal Process Cholesterol Transport Mitochondrion Macrophage Activation Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Crotonyl-CoA Hydratase Activity Creatine Biosynthetic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Dendrite Regeneration Positive Regulation Of Reverse Cholesterol Transport Negative Regulation Of Cytoplasmic Translational Initiation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Regulation Of Cell Population Proliferation Cognition
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?