AMD1 and THAP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AMD1	THAP4
Description		adenosylmethionine decarboxylase 1	THAP domain containing 4
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GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Adenosylmethionine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity Putrescine Binding Identical Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Isomerase Activity Heme Binding Identical Protein Binding Metal Ion Binding Peroxynitrite Isomerase Activity Nitric Oxide Binding
	Biological Process	Polyamine Metabolic Process Polyamine Biosynthetic Process Spermine Biosynthetic Process Spermidine Biosynthetic Process	Tyrosine Metabolic Process Nitrate Metabolic Process
Pathways		Metabolism of polyamines
Drugs		Ademetionine Putrescine 5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine
Diseases
GWAS		Blood metabolite levels ( 26401656)	Brain structure ( 20171287) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Platelet count ( 32888494) Prostate cancer ( 23535732) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		2 interacting genes: HSPB1 THAP4	43 interacting genes: AGTRAP AIG1 AMD1 ANKRD46 APP BSND CACNG1 CD81 CLCA4 CMTM5 CMTM7 COL4A5 CPNE2 CTSA CYP4F2 DGAT2L6 FKBP7 GIMAP1 GPR37L1 IGFBP5 LAT LCOR LPAR3 MAL2 MAPK6 MOB4 MS4A1 NDRG4 PLP2 RMDN2 RTP2 SCAMP1 SLC30A8 SYP TMEM107 TMEM60 TMEM86A TMEM86B TNFRSF10D TPD52 TRIM54 TTPA YIPF6
Entrez ID		262	51078
HPRD ID		01622	11630
Ensembl ID		ENSG00000123505	ENSG00000176946
Uniprot IDs		A0A088AWN0 B4DZ60 P17707 Q5VXN5	Q8WY91
PDB IDs		1I72 1I79 1I7B 1I7C 1I7M 1JEN 1JL0 1MSV 3DZ2 3DZ3 3DZ4 3DZ5 3DZ6 3DZ7 3EP3 3EP4 3EP5 3EP6 3EP7 3EP8 3EP9 3EPA 3EPB 3H0V 3H0W	3IA8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Kinase C Signaling Peroxynitrite Isomerase Activity Protein Kinase C Inhibitor Activity Nitrate Metabolic Process Regulation Of Protein Kinase C Signaling Nitric Oxide Binding Anterograde Axonal Protein Transport Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Tyrosine Metabolic Process Protein Refolding Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Reactive Nitrogen Species Metabolic Process Aromatic Amino Acid Metabolic Process Protein Localization To Synapse Positive Regulation Of Blood Vessel Endothelial Cell Migration Protein Folding Chaperone Protein Kinase C Binding Platelet Aggregation Axon Cytoplasm Positive Regulation Of Interleukin-1 Beta Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Transport Anterograde Axonal Transport Cornified Envelope Proteasome Complex Homotypic Cell-cell Adhesion Positive Regulation Of Interleukin-1 Production	Membrane Alkenylglycerophosphocholine Hydrolase Activity Vitamin E Metabolic Process
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