PTPN20 and ARHGAP22

		PTPN20	ARHGAP22
Description		protein tyrosine phosphatase non-receptor type 20	Rho GTPase activating protein 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Microtubule Centriolar Satellite	Nucleus Cytoplasm Cytosol Focal Adhesion Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Hydrolase Activity	GTPase Activator Activity Protein Binding
	Biological Process	Lymphangiogenesis	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Organization
Pathways		Interleukin-37 signaling	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS			Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Femur bone mineral density x serum urate levels interaction ( 34046847) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)
Interacting Genes		6 interacting genes: AATK EGFR ERBB3 ERBB4 KIT ROR2	8 interacting genes: CACNA1A CCNDBP1 CDC42 DEF6 FXR1 IL1RAPL1 RAC1 RHOA
Entrez ID		26095	58504
HPRD ID		10898	12476
Ensembl ID		ENSG00000204179	ENSG00000128805
Uniprot IDs		Q4JDK3 Q4JDL3	A0A2X0SFC0 Q7Z5H3
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex ERBB2 Signaling Pathway ATP Binding Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Basolateral Plasma Membrane Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Growth Factor Binding Positive Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Peptidyl-tyrosine Phosphorylation Animal Organ Development Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Response To Light Stimulus Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction JUN Phosphorylation Clathrin-coated Endocytic Vesicle Membrane	Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Projection G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Dendrite G Protein Activity Postsynapse Positive Regulation Of Cellular Component Biogenesis Thioesterase Binding Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Regulation Of Stress Fiber Assembly Regulation Of Synapse Organization Establishment Of Epithelial Cell Apical/basal Polarity GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Postsynapse Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Protein-containing Complex Assembly Phagocytosis, Engulfment Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Development Cell-cell Junction Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein-containing Complex Assembly Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-substrate Adhesion Forebrain Cell Migration Positive Regulation Of Neurogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity
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