SETBP1 and SPANXC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SETBP1	SPANXC
Description		SET binding protein 1	SPANX family member C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Histone H3K4 Methyltransferase Activity	Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases		Schinzel-Giedion midface retraction syndrome
GWAS		Adult body size ( 32376654) Bone ultrasound measurement (velocity of sound) ( 28472463) Breast cancer ( 29059683 25751625 31757997) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Coronary artery aneurysm in Kawasaki disease ( 27171184) Diastolic blood pressure ( 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 31152163) Hair color ( 26926045) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 22693459 29146897 28196072) Mean platelet volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Neonatal white matter microstructure ( 33009551) Number of sexual partners ( 30643258) Platelet thrombus formation ( 22550155) Pulse pressure ( 27841878) QRS duration ( 30012220 30679814 27577874 25035420 27659466) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) Restless legs syndrome ( 29029846) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 28739976 27618452 27841878) Waist circumference ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		13 interacting genes: APP DENND11 LRRC37A11P PLEKHF2 SET SPANXA1 SPANXA2 SPANXC SPANXD SUMO1P1 UBE2I XAGE1B YAF2	2 interacting genes: LMNA SETBP1
Entrez ID		26040	64663
HPRD ID		10224	02270
Ensembl ID		ENSG00000152217	ENSG00000198573
Uniprot IDs		A0A7I2V4X1 Q9Y6X0	Q9NY87
PDB IDs
Enriched GO Terms of Interacting Partners?			Nuclear Lamina Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Ventricular Cardiac Muscle Cell Development Chromatin Remodeling Protein Localization To Nuclear Envelope Nuclear Pore Localization Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Structural Constituent Of Nuclear Lamina Histone H3K4 Methyltransferase Activity Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Chromatin Organization Nuclear Envelope Organization Nuclear Migration Nucleus Localization Nuclear Lumen Negative Regulation Of Muscle Hypertrophy Cardiac Muscle Cell Development Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Release Of Cytochrome C From Mitochondria Cardiac Cell Development Cellular Senescence Striated Muscle Cell Development Protein-containing Complex Localization Regulation Of Cardiac Muscle Hypertrophy Chromosome Localization Nucleus Organization
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