SETBP1 and SPANXD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SETBP1	SPANXD
Description		SET binding protein 1	SPANX family member D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Histone H3K4 Methyltransferase Activity	Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases		Schinzel-Giedion midface retraction syndrome
GWAS		Adult body size ( 32376654) Bone ultrasound measurement (velocity of sound) ( 28472463) Breast cancer ( 29059683 25751625 31757997) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Coronary artery aneurysm in Kawasaki disease ( 27171184) Diastolic blood pressure ( 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 31152163) Hair color ( 26926045) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 22693459 29146897 28196072) Mean platelet volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Neonatal white matter microstructure ( 33009551) Number of sexual partners ( 30643258) Platelet thrombus formation ( 22550155) Pulse pressure ( 27841878) QRS duration ( 30012220 30679814 27577874 25035420 27659466) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) Restless legs syndrome ( 29029846) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 28739976 27618452 27841878) Waist circumference ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		13 interacting genes: APP DENND11 LRRC37A11P PLEKHF2 SET SPANXA1 SPANXA2 SPANXC SPANXD SUMO1P1 UBE2I XAGE1B YAF2	3 interacting genes: FLNA LMNA SETBP1
Entrez ID		26040	64648
HPRD ID		10224	06722
Ensembl ID		ENSG00000152217	ENSG00000196406
Uniprot IDs		A0A7I2V4X1 Q9Y6X0	Q9BXN6
PDB IDs
Enriched GO Terms of Interacting Partners?			Glycoprotein Ib-IX-V Complex Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Fc-gamma Receptor I Complex Binding Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Formation Of Radial Glial Scaffolds Tubulin Deacetylation Regulation Of Protein Localization To Nucleus Myb Complex Establishment Of Sertoli Cell Barrier Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Pore Localization Structural Constituent Of Nuclear Lamina Blood Coagulation, Intrinsic Pathway Protein Localization To Bicellular Tight Junction Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Protein Stability Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Mesenchymal Cell Proliferation Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Integrin-mediated Signaling Pathway Apical Dendrite Positive Regulation Of Neuron Migration Positive Regulation Of Platelet Activation Actin Crosslink Formation Microtubule Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase I Localization Within Membrane Protein Deacetylation Sertoli Cell Development Nuclear Lamina Ventricular Cardiac Muscle Cell Development Protein Localization To Nuclear Envelope Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Histone H3K4 Methyltransferase Activity Protein Localization To Cell-cell Junction Protein Activation Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Integrin-mediated Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Megakaryocyte Development Nuclear Envelope Organization Chromatin Remodeling Macromolecule Deacylation Positive Regulation Of Potassium Ion Transmembrane Transport Nuclear Migration Cortical Cytoskeleton Perinuclear Region Of Cytoplasm
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