DNAH1 and LIN7B

		DNAH1	LIN7B
Description		dynein axonemal heavy chain 1	lin-7 cell polarity scaffold B
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Inner Dynein Arm Cell Projection	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Sperm Axoneme Assembly Flagellated Sperm Motility Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport
Pathways			Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Chronotype ( 30696823) Electroencephalogram traits ( 25387704) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes			19 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP7 NTAQ1 PSMB1 SNCA TCEANC TRAPPC12
Entrez ID		25981	64130
HPRD ID		11790	10040
Ensembl ID		ENSG00000114841	ENSG00000104863
Uniprot IDs		A0A140VJI6 Q9P2D7	Q9HAP6
PDB IDs		8I3J 8J07	2DKR
Enriched GO Terms of Interacting Partners?		DNA/RNA Helicase Activity RNA Binding TRNA Processing Growth Plate Cartilage Chondrocyte Development Positive Regulation Of Centrosome Duplication Chondrocyte Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Protein Localization To Chromosome, Telomeric Region O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec MPP7-DLG1-LIN7 Complex	Modulation Of Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity PDZ Domain Binding Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Regulation Of Nervous System Process Ligand-gated Ion Channel Signaling Pathway Cellular Component Assembly Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Protein-containing Complex Assembly Glutamate-gated Calcium Ion Channel Activity Excitatory Postsynaptic Potential Plasma Membrane Synapse Synaptic Membrane Scaffold Protein Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Monoatomic Ion Transport Regulation Of Protein-containing Complex Assembly Protein-containing Complex Organization Protein Localization To Cell Junction Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Protein Tetramerization Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Postsynaptic Membrane Potential Neuron Projection Terminus Postsynaptic Density Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Inward Rectifier Potassium Channel Activity Regulation Of System Process Dendrite Cytoplasm Monoatomic Ion Transport Synaptic Vesicle Metal Ion Transport Regulation Of Presynaptic Membrane Potential Cell-cell Signaling Excitatory Synapse Ligand-gated Monoatomic Ion Channel Activity
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