PNKD and GMPPA

		PNKD	GMPPA
Description		PNKD metallo-beta-lactamase domain containing	GDP-mannose pyrophosphorylase A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Presynaptic Cytosol	Cytoplasm Cytosol Extracellular Exosome GDP-mannose Pyrophosphorylase Complex
	Molecular Function	Hydroxyacylglutathione Hydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Mannose-1-phosphate Guanylyltransferase (GTP) Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Enzyme Binding Molecular Sensor Activity
	Biological Process	Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Negative Regulation Of Neurotransmitter Secretion Neuromuscular Process Controlling Posture	Protein Glycosylation Glycoprotein Metabolic Process GDP-mannose Biosynthetic Process Negative Regulation Of Biosynthetic Process GDP-mannose Metabolic Process Telencephalon Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Muscle Organ Morphogenesis Cognition Neuromuscular Process Neuron Apoptotic Process Skeletal Muscle Organ Development Motor Behavior Negative Regulation Of Small Molecule Metabolic Process
Pathways			Synthesis of GDP-mannose
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Appendicular lean mass ( 33097823) Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Glycated hemoglobin levels ( 34059833) Granulocyte count ( 27863252) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) White blood cell count ( 27863252)
Interacting Genes		7 interacting genes: APP ENO3 KCTD9 KLHL20 MAGEA11 MYL12B UBC	10 interacting genes: AKT1 BTC CDR2 CRP DCUN1D1 GMPPB GPKOW LSM8 NCK1 ZNF688
Entrez ID		25953	29926
HPRD ID		11369	13588
Ensembl ID		ENSG00000127838	ENSG00000144591
Uniprot IDs		Q8N490	A0A384MDS7 Q96IJ6
PDB IDs			7D72 7D73 7D74
Enriched GO Terms of Interacting Partners?			Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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