FAM98A and ZCCHC9

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		FAM98A	ZCCHC9
Description		family with sequence similarity 98 member A	zinc finger CCHC-type containing 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm TRNA-splicing Ligase Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Binding Protein Binding Protein Methyltransferase Activity	Nucleic Acid Binding RNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Protein Methylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Lysosome Localization Positive Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Irritable bowel syndrome ( 29626450) Metabolite levels ( 23823483) Non-response to antidepressants and depression ( 27622933) Perceived intensity of aspartame ( 31005972) Response to antidepressants in depression ( 27622933) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		67 interacting genes: EMG1 MIR1-2 MIR106A MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT SNCA ZCCHC9	3 interacting genes: EMG1 FAM98A UBTFL1
Entrez ID		25940	84240
HPRD ID		16808	15704
Ensembl ID		ENSG00000119812	ENSG00000131732
Uniprot IDs		B4DT23 I6L9E8 Q8NCA5	Q8N567
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Negative Regulation Of Cytokine Production MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production RNA Destabilization Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Migration	RRNA (pseudouridine) Methyltransferase Activity Macromolecule Methylation Nucleologenesis RRNA Base Methylation Nucleolus Organization RNA Metabolic Process Methylation TRNA-splicing Ligase Complex RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Blastocyst Growth RNA Polymerase I Preinitiation Complex Assembly TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Protein Methyltransferase Activity Positive Regulation Of Ruffle Assembly Transcription By RNA Polymerase I RRNA Methylation Nucleic Acid Metabolic Process Blastocyst Development Regulation Of Ruffle Assembly Positive Regulation Of Transcription By RNA Polymerase I RRNA Modification Protein Methylation RRNA Binding Regulation Of Transcription By RNA Polymerase I Embryo Implantation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
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