FAM98A and MIR200A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		FAM98A	MIR200A
Description		family with sequence similarity 98 member A	microRNA 200a
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm TRNA-splicing Ligase Complex	RISC Complex
	Molecular Function	RNA Binding Protein Binding Protein Methyltransferase Activity	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Protein Methylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Lysosome Localization Positive Regulation Of Ruffle Assembly	MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Amyloid-beta
Pathways
Drugs
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Irritable bowel syndrome ( 29626450) Metabolite levels ( 23823483) Non-response to antidepressants and depression ( 27622933) Perceived intensity of aspartame ( 31005972) Response to antidepressants in depression ( 27622933) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		67 interacting genes: EMG1 MIR1-2 MIR106A MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT SNCA ZCCHC9	76 interacting genes: ADARB1 APOBEC3B C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NONO PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBM45 RTCA RTCB SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TRA2B UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		25940	406983
HPRD ID		16808
Ensembl ID		ENSG00000119812	ENSG00000207607
Uniprot IDs		B4DT23 I6L9E8 Q8NCA5
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Negative Regulation Of Cytokine Production MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production RNA Destabilization Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex Macromolecule Metabolic Process Nucleus MiRNA Binding Nucleoplasm Negative Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Translation Catalytic Step 2 Spliceosome Spliceosomal Complex Cytoplasmic Stress Granule MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Stabilization Regulation Of RNA Stability Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cytoplasmic Translation Regulation Of Metabolic Process Ligase Activity Negative Regulation Of Metabolic Process P-body
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