GALNT2 and MRM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GALNT2	MRM3
Description		polypeptide N-acetylgalactosaminyltransferase 2	mitochondrial rRNA methyltransferase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Carbohydrate Binding Metal Ion Binding	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Identical Protein Binding RRNA (guanosine-2'-O-)-methyltransferase Activity
	Biological Process	Positive Regulation Of Immunoglobulin Production Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein Maturation	RRNA 2'-O-methylation RRNA Processing RNA Processing Methylation
Pathways		COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins	rRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Carotid intima media thickness ( 26343869) Circulating myeloperoxidase levels (serum) ( 23620142) Coronary artery disease ( 29212778) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Fibrinogen levels ( 28107422) HDL cholesterol ( 30275531 18193043 18193044 19060906 25961943 24097068 20864672 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematology traits ( 23303382) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817 29403010) Intake of sweets ( 31005972) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552 22399527) Metabolite levels ( 22916037) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Postburn scar pliability ( 30595539) Red cell distribution width ( 28957414 27863252 32888494) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32902719 33339817 32203549 32154731 30698716 29403010 28334899) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531 25961943 24097068 20686565 18193044 18193043)
Interacting Genes		10 interacting genes: BCL2L13 CDC42 COQ9 GOLPH3 GOLPH3L KASH5 LCOR LMNA MRM3 MUC1	16 interacting genes: AIG1 APP ARLN BTN2A2 FBXO7 FHL3 GAD2 GALNT2 JAGN1 MIP OGT SCARF1 SHANK3 TNF UBIAD1 ZFPL1
Entrez ID		2590	55178
HPRD ID		03782	15266
Ensembl ID		ENSG00000143641	ENSG00000171861
Uniprot IDs		A0A1L7NY50 B7Z6K2 Q10471	Q9HC36
PDB IDs		2FFU 2FFV 4D0T 4D0Z 4D11 5AJN 5AJO 5AJP 5FV9 5NDF 6E7I 6EGS 6NQT	7OI6
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Golgi Organization Nuclear Migration Phosphatidylinositol-4-phosphate Binding Nucleus Localization Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Membrane Organization Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Isoprenoid Binding Golgi Cisterna Membrane GBD Domain Binding Storage Vacuole DNA Double-strand Break Attachment To Nuclear Envelope Chromosome Localization Establishment Of Protein Localization To Organelle Structural Constituent Of Nuclear Lamina RRNA (guanosine-2'-O-)-methyltransferase Activity Lipid Binding Asymmetric Golgi Ribbon Formation Meiotic Spindle Pole Organelle Organization Aerobic Respiration Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Respiration RRNA 2'-O-methylation Post-Golgi Vesicle-mediated Transport Cell Adhesion Molecule Production Cellular Response To Rapamycin Regulation Of Mitochondrion Organization Organelle Localization Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein Retention In Golgi Apparatus Vesicle-mediated Transport To The Plasma Membrane Lamin Filament Localization Within Membrane Nuclear Pore Localization	Positive Regulation Of Proteolysis Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Neuron Projection Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Synapse Organization Membrane Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Neuron Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Regulation Of Amyloid-beta Clearance Positive Regulation Of Long-term Synaptic Potentiation Astrocyte Activation Positive Regulation Of Synaptic Transmission Positive Regulation Of Developmental Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Development Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Nervous System Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Neuron Remodeling Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Positive Regulation Of Translational Initiation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Branching Involved In Lung Morphogenesis Response To Monosaccharide Response To Carbohydrate Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Modulation Of Excitatory Postsynaptic Potential Cellular Response To Amyloid-beta
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