FBXL2 and DYNC1LI1

		FBXL2	DYNC1LI1
Description		F-box and leucine rich repeat protein 2	dynein cytoplasmic 1 light intermediate chain 1
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GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Dynein Complex Endocytic Vesicle Membrane Secretory Granule Membrane Recycling Endosome Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding GDP Binding Protein-macromolecule Adaptor Activity Dynein Heavy Chain Binding Molecular Adaptor Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Protein Modification Process Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Microtubule Cytoskeleton Organization Microtubule-based Movement Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
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Diseases
GWAS		Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Rostral anterior cingulate cortex volume ( 31530798)	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 33339817)
Interacting Genes		14 interacting genes: APP AURKB CCND2 CDC34 COL7A1 EGFR IL1B NLRP3 PIK3R2 RBX1 SKP1 UBE2D1 UBE2D3 UBE2G1	11 interacting genes: BRCA2 CEBPA IKBKG NOP56 NUP85 OGT PGAM2 RAB4A REL RUFY1 SLC25A21-AS1
Entrez ID		25827	51143
HPRD ID		05736	10917
Ensembl ID		ENSG00000153558	ENSG00000144635
Uniprot IDs		B4E1B8 Q9UKC9	B3KM42 E9PHI6 Q9Y6G9
PDB IDs		6O60	6B9H 6PSD 6PSE
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Mitotic Cell Cycle Protein Polyubiquitination Positive Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signaling Cytosol Negative Regulation Of Cell Communication Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Cul7-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Signal Transduction Cell Cycle Phase Transition Regulation Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Radiation Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Cellular Response To Oxygen-containing Compound Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Astrocyte Activation Positive Regulation Of Cell Cycle Checkpoint Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signaling Response To Light Stimulus
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