BACE2 and POFUT2

		BACE2	POFUT2
Description		beta-secretase 2	protein O-fucosyltransferase 2
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity Peptide-O-fucosyltransferase Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Protein Processing Peptide Hormone Processing Melanosome Organization Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid-beta Metabolic Process	Mesoderm Formation Fucose Metabolic Process Protein Glycosylation Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Fucosylation Protein O-linked Glycosylation Via Fucose Regulation Of Secretion Positive Regulation Of Protein Folding
Pathways			O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)	Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		5 interacting genes: APP GGA1 GGA2 PCM1 SNRNP70
Entrez ID		25825	23275
HPRD ID		05744	09846
Ensembl ID		ENSG00000182240	ENSG00000186866
Uniprot IDs		Q9Y5Z0	Q9Y2G5 S6FW71
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1 7D5B 7D5U 7F1G 7N4N	4AP5 4AP6
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Folding	Bicellular Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Membrane Protein Ectodomain Proteolysis Melanosome Membrane Regulation Of Glycoprotein Biosynthetic Process Melanosome Organization Amyloid-beta Metabolic Process Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Aspartic-type Endopeptidase Activity Pigment Granule Organization Regulation Of Amyloid Precursor Protein Biosynthetic Process Membrane Protein Proteolysis Tight Junction Assembly Tight Junction Organization Endoplasmic Reticulum Melanosome
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