POFUT2

Description		protein O-fucosyltransferase 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus
	Molecular Function	Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity Peptide-O-fucosyltransferase Activity
	Biological Process	Mesoderm Formation Fucose Metabolic Process Protein Glycosylation Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Fucosylation Protein O-linked Glycosylation Via Fucose Regulation Of Secretion Positive Regulation Of Protein Folding
Pathways		O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Suicide attempt severity in mood disorders ( 33783297)
Novel Interacting Genes		2 novel interacting genes: BACE2 CLDN14
Interacting Genes
Entrez ID		23275
HPRD ID		09846
Ensembl ID		ENSG00000186866
Uniprot IDs		Q9Y2G5 S6FW71
PDB IDs		4AP5 4AP6
Enriched GO Terms of Interacting Partners?		Bicellular Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Membrane Protein Ectodomain Proteolysis Melanosome Membrane Regulation Of Glycoprotein Biosynthetic Process Melanosome Organization Amyloid-beta Metabolic Process Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Aspartic-type Endopeptidase Activity Pigment Granule Organization Regulation Of Amyloid Precursor Protein Biosynthetic Process Membrane Protein Proteolysis Tight Junction Assembly Tight Junction Organization Endoplasmic Reticulum Melanosome
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