SUN2 and APOBEC3C

		SUN2	APOBEC3C
Description		Sad1 and UNC84 domain containing 2	apolipoprotein B mRNA editing enzyme catalytic subunit 3C
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Nuclear Envelope Nuclear Inner Membrane Endosome Endosome Membrane Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	P-body Nucleus Cytoplasm
	Molecular Function	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein-membrane Adaptor Activity Cytoskeleton-nuclear Membrane Anchor Activity	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Nuclear Matrix Anchoring At Nuclear Membrane	Immune System Process Transposable Element Silencing Negative Regulation Of Macromolecule Biosynthetic Process Cytidine To Uridine Editing Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Clearance Of Foreign Intracellular DNA Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination Defense Response To Symbiont
Pathways		Meiotic synapsis	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS		Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		6 interacting genes: HGS NRM PRPF6 RAB5B RPS20 SRSF10	30 interacting genes: ARIH2 CHTOP CUL5 FBXO7 HHEX HNRNPK MYO10 NXF1 PCBP2 PCBP3 PRPF31 PRR3 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J SF1 SHBG SNRPA SNW1 SRPK2 TRAF3 TRIB3 UBC UNKL ZNF250 ZNF408 ZNF48 ZNF581
Entrez ID		25777	27350
HPRD ID		15611	09671
Ensembl ID		ENSG00000100242	ENSG00000244509
Uniprot IDs		B0QY60 B0QY64 B4E2A6 Q9UH99	Q9NRW3
PDB IDs		3UNP 4DXR 4DXS 4DXT 4FI9 6WMD 6WME 6WMF 6WMG	3VM8 3VOW
Enriched GO Terms of Interacting Partners?		Endosome Organization Spliceosomal Tri-snRNP Complex Assembly	Spliceosomal Complex MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Binding RNA Splicing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding MRNA Processing Nucleus Positive Regulation Of RNA Splicing RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Metabolic Process Identical Protein Binding Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Viral RNA Genome Replication Nucleobase-containing Compound Metabolic Process Transcription Export Complex Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Cul5-RING Ubiquitin Ligase Complex Negative Regulation Of CGAS/STING Signaling Pathway Protein Binding Regulation Of Gene Expression Catalytic Step 2 Spliceosome Viral Genome Replication Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Protein K48-linked Ubiquitination Nuclear Speck Ubiquitin Ligase Complex Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process CGAS/STING Signaling Pathway Ubiquitin-protein Transferase Activity Nucleolus 14-3-3 Protein Binding
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