PLPP4 and FRMD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLPP4	FRMD3
Description		phospholipid phosphatase 4	FERM domain containing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoskeleton Membrane
	Molecular Function	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Identical Protein Binding	Protein Binding Cytoskeletal Protein Binding
	Biological Process	Blastocyst Hatching Lipid Metabolic Process Phospholipid Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phospholipid Dephosphorylation Regulation Of Calcium Ion Import	Actomyosin Structure Organization
Pathways		Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Blood pressure traits (multi-trait analysis) ( 28498854) Hypertension ( 28498854) Insulin sensitivity index ( 24699409) Lewy body disease ( 25188341) Loneliness (multivariate analysis) ( 27629369) Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: ANKRD46 ARL13B BCL2L13 BIK BMP10 CD74 CISD2 CPLX4 CREB3L1 CYB5B ERGIC3 EVI2A FAM209A FRMD3 GET1 GJA1 GJB5 GPX8 LMNA LRRC59 MGST3 PAGE1 PDZK1IP1 PSCA SGPL1 SLC35A1 SSMEM1 STX1A STX2 SYT2 TMEM139 TMEM45B UPK1B	12 interacting genes: CMTM7 CYB5B JAGN1 NRM PLPP4 SERP1 SERP2 SLC35A4 TMEM201 TMEM218 TMEM97 ZFPL1
Entrez ID		196051	257019
HPRD ID		18745	07402
Ensembl ID		ENSG00000203805	ENSG00000172159
Uniprot IDs		Q5VZY2	A2A2Y4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNARE Binding Endoplasmic Reticulum Membrane SNARE Complex Ventricular Cardiac Muscle Cell Development	Membrane Nuclear Membrane Nuclear Inner Membrane Protein Localization To Extracellular Region Hormone Secretion Insulin Secretion Peptide Hormone Secretion Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Hormone Transport Endoplasmic Reticulum Unfolded Protein Response Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Protein Transport Peptide Transport Peptide Secretion Positive Regulation Of Lipoprotein Transport Nitric-oxide Synthase Complex Nitrite Reductase (NO-forming) Activity Granulocyte Colony-stimulating Factor Signaling Pathway B-1a B Cell Differentiation B-1 B Cell Differentiation Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Diacylglycerol Diphosphate Phosphatase Activity Nuclear Migration Along Microtubule
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