CCDC110 and DEPTOR

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CCDC110	DEPTOR
Description		coiled-coil domain containing 110	DEP domain containing MTOR interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cytoskeleton	Lysosome Lysosomal Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Lipid Binding Protein Serine/threonine Kinase Inhibitor Activity Phosphatidic Acid Binding
	Biological Process		Autophagosome Assembly Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Cell Size Negative Regulation Of TORC2 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			A body shape index ( 34021172) Choroid plexus volume ( 31530798) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Idiopathic pulmonary fibrosis ( 31710517) Platelet count ( 32888494) Plateletcrit ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		2 interacting genes: CFTR DEPTOR	13 interacting genes: ANKRD11 APP CCDC110 CHKA CUL5 FBXO25 LNX1 MAPK3 PSME3 RPS6KA1 RPS6KB1 TRAF1 TRIM41
Entrez ID		256309	64798
HPRD ID		11335	13137
Ensembl ID		ENSG00000168491	ENSG00000155792
Uniprot IDs		E7EUS2 Q8TBZ0	Q8TB45
PDB IDs			7DKL 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7PED
Enriched GO Terms of Interacting Partners?		Lysosomal Membrane Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of TORC2 Signaling Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Negative Regulation Of Cell Size ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Regulation Of TORC2 Signaling Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Water Transport Bicarbonate Transport Phosphatidic Acid Binding Protein Serine/threonine Kinase Inhibitor Activity Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Protein Kinase Inhibitor Activity Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Cholesterol Transport Membrane Docking	Regulation Of Extrinsic Apoptotic Signaling Pathway TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Cytosol Identical Protein Binding Protein Modification Process Face Development ERBB2 Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of TOR Signaling Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Signal Transduction Positive Regulation Of Defense Response Apoptotic Process Protein Metabolic Process Programmed Cell Death Negative Regulation Of Signaling Cell Death Negative Regulation Of Cell Communication Regulation Of Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Choline Kinase Activity Kinase Activity Cellular Response To Nutrient Levels SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Ubiquitination Transferase Activity SCF Ubiquitin Ligase Complex Glial Cell Development Negative Regulation Of TORC1 Signaling Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cell Communication Positive Regulation Of Protein Import Regulation Of Signaling ERBB Signaling Pathway Protein Modification By Small Protein Conjugation Symbiont-mediated Suppression Of Host Innate Immune Response PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Growth Factor Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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