SMCO1 and SGK3

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		SMCO1	SGK3
Description		single-pass membrane protein with coiled-coil domains 1	serum/glucocorticoid regulated kinase family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Cytoplasm Endosome Early Endosome Cytosol Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Phosphatidylinositol Binding Protein Serine Kinase Activity
	Biological Process		Regulation Of Cell Growth Protein Phosphorylation Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Stimuli-sensing channels
Drugs			Fostamatinib
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		3 interacting genes: CREB1 FNDC8 SGK3	7 interacting genes: APP GSK3A GSK3B ITCH NHERF2 PDPK1 SMCO1
Entrez ID		255798	23678
HPRD ID		19011	06349
Ensembl ID		ENSG00000214097	ENSG00000104205
Uniprot IDs		Q147U7	Q53EW6 Q96BR1
PDB IDs			6EDX
Enriched GO Terms of Interacting Partners?		Response To Dehydroepiandrosterone Positive Regulation Of Cardiac Muscle Tissue Development ATF4-CREB1 Transcription Factor Complex Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Phosphorylation Response To Hypobaric Hypoxia Chemotaxis To Arachidonate Lung Saccule Development Response To Erythropoietin Regulation Of Testosterone Biosynthetic Process Chloride Channel Regulator Activity Arrestin Family Protein Binding Type I Pneumocyte Differentiation Phosphorylation CAMP/PKA Signal Transduction Positive Regulation Of Membrane Depolarization Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Growth Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Striated Muscle Tissue Development Lung Epithelium Development CAMP Response Element Binding Cellular Response To Zinc Ion Cellular Response To Forskolin Response To L-glutamate Response To Forskolin Cellular Response To Insulin-like Growth Factor Stimulus Response To Glucagon Response To Hepatocyte Growth Factor Response To Morphine Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Ketone Biosynthetic Process Positive Regulation Of Long-term Synaptic Potentiation Response To Platelet-derived Growth Factor Lung Epithelial Cell Differentiation Histone Acetyltransferase Binding Lung Cell Differentiation Positive Regulation Of Osteoclast Differentiation Pituitary Gland Development Response To Zinc Ion Regulation Of Striated Muscle Tissue Development Lactation Response To Nicotine Regulation Of Muscle Organ Development Negative Regulation Of Apoptotic Process Positive Regulation Of Multicellular Organism Growth Response To Nerve Growth Factor	Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cellular Response To Interleukin-3 C-X-C Chemokine Receptor CXCR4 Signaling Pathway Signaling Receptor Activator Activity Regulation Of Type B Pancreatic Cell Development Insulin Receptor Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Signaling Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Beta-catenin Destruction Complex Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Extrinsic Apoptotic Signaling Pathway Protein Kinase A Catalytic Subunit Binding Signaling Receptor Binding Protein Autophosphorylation Regulation Of Protein Localization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Tolerance Induction Regulation Of Calcium Ion Transmembrane Transport Tau-protein Kinase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Adhesion Protein Kinase Activity Response To Insulin Negative Regulation Of Wnt Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Ephrin Receptor Binding
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