GABPA and TMPRSS15

		GABPA	TMPRSS15
Description		GA binding protein transcription factor subunit alpha	transmembrane serine protease 15
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Brush Border Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Proteolysis
Pathways		Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases			Enterokinase deficiency
GWAS		Glaucoma (primary open-angle) ( 33627673) Gout (normal type) ( 32238385) Nicotine dependence symptom count ( 25555482)	Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)
Interacting Genes		14 interacting genes: APP ATF1 CEBPA CREBBP EP300 GABPB1 HCFC1 MED1 OGT PINX1 SP1 SP3 STK16 ZC2HC1B	1 interacting genes: SPINK1
Entrez ID		2551	5651
HPRD ID		11793	05972
Ensembl ID		ENSG00000154727	ENSG00000154646
Uniprot IDs		A8IE48 Q06546 Q8IYS3	P98073
PDB IDs			4DGJ 6ZOV 7WQX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hemopoiesis DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Protein Localization To Nucleus Transcription Coactivator Binding Regulation Of Glycolytic Process Chromatin Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Defense Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of ATP Metabolic Process STAT Family Protein Binding NSL Complex	Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Adenine Biosynthetic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Adenine Metabolic Process
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