RICTOR and PLCXD3

		RICTOR	PLCXD3
Description		RPTOR independent companion of MTOR complex 2	phosphatidylinositol specific phospholipase C X domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane TORC2 Complex Serine/threonine Protein Kinase Complex	Cytoplasm Synapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Enzyme-substrate Adaptor Activity	Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cytoskeleton Organization Lipid Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Establishment Of Cell Polarity	Lipid Metabolic Process Signal Transduction Lipid Catabolic Process
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Carbocisteine
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)	Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB MTOR PLK1 SGK1 SIRT1 USP9X	2 interacting genes: MAGEA11 P4HB
Entrez ID		253260	345557
HPRD ID		10682	17860
Ensembl ID		ENSG00000164327	ENSG00000182836
Uniprot IDs		A0AA34QVX7 D6R9S6 Q6R327	B3KXD1 Q63HM9
PDB IDs		5ZCS 6ZWM 6ZWO 7PE7 7PE8 7PE9 7TZO
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Beta-catenin Destruction Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of TORC2 Signaling Protein Destabilization Regulation Of Cellular Response To Heat Protein Kinase Activity Cytoplasm Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process IkappaB Kinase Activity Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of TORC2 Signaling Regulation Of Glycogen (starch) Synthase Activity Regulation Of Organelle Assembly Proteasomal Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Proteolysis Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process IkappaB Kinase Complex Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-3 Cell Cycle Phase Transition Regulation Of Type B Pancreatic Cell Development	Interleukin-23-mediated Signaling Pathway Cellular Response To Interleukin-7 Positive Regulation Of Locomotion Procollagen-proline 4-dioxygenase Activity Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Positive Regulation Of Cell Migration Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Viral Entry Into Host Cell Insulin Metabolic Process Protein Disulfide Isomerase Activity Response To Interleukin-7 Insulin Processing Thiol Oxidase Activity Positive Regulation Of Cell Motility Regulation Of Viral Entry Into Host Cell Protein Hydroxylation Interleukin-12-mediated Signaling Pathway Protein Folding In Endoplasmic Reticulum Peptidyl-proline Hydroxylation Procollagen-proline 4-dioxygenase Complex TORC2 Complex Enzyme-substrate Adaptor Activity TORC2 Signaling Negative Regulation Of CGAS/STING Signaling Pathway Serine/threonine Protein Kinase Complex Regulation Of Establishment Of Cell Polarity Protein-disulfide Reductase Activity Positive Regulation Of Viral Life Cycle Regulation Of Establishment Or Maintenance Of Cell Polarity CGAS/STING Signaling Pathway
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