FUT3 and SLC41A2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FUT3	SLC41A2
Name		fucosyltransferase 3 (Lewis blood group)	solute carrier family 41 member 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Protein Binding Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase Activity 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity	Protein Binding Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein O-linked Glycosylation Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Oligosaccharide Metabolic Process Oligosaccharide Biosynthetic Process Cell-cell Recognition Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Migration Fucosylation Regulation Of Cell Population Proliferation Macromolecule Glycosylation	Monoatomic Ion Transport Monoatomic Cation Transport Cobalt Ion Transport Iron Ion Transport Manganese Ion Transport Nickel Cation Transport Magnesium Ion Transport Metal Ion Transport Magnesium Ion Transmembrane Transport
Pathways		Lewis blood group biosynthesis Reactions specific to the complex N-glycan synthesis pathway	Metal ion SLC transporters
GWAS		Blood protein levels ( 30072576 ) Elevated serum carcinoembryonic antigen levels ( 24941225 ) N-glycan levels ( 21203500 21908519 ) Serum alkaline phosphatase levels ( 33547301 ) Serum cancer antigen 19.9 levels ( 31666285 ) Vitamin B12 levels ( 28334792 )	Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170 ) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292 )
Novel Interactors		1 novel interactors: AKAP6	1 novel interactors: CKAP4
Interacting Genes		5 interacting genes: C3orf52 SEC22A SLC41A2 TRARG1 WWP2	31 interacting genes: AQP6 CD79A CLN5 CREB3 EBP ERGIC3 ERVFRD-1 FATE1 FNDC9 FUT3 GJA5 GJB5 GPR151 GPR42 GPX8 IGFBP5 IL27RA KASH5 KIR3DL3 LDLRAD1 LEUTX LIME1 LMNA LY6G6C LYVE1 MFF PDCD1LG2 PVR SHISAL1 SSMEM1 TMEM237
Entrez ID		2525	84102
HPRD ID		00196	15389
Ensembl ID		ENSG00000171124	ENSG00000136052
Uniprot IDs		A8K737 P21217	Q96JW4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Membrane B Cell Receptor Complex