FSHB and CGA

Number of citations of the paper that reports this interaction (PubMedID 10563789)
0

Data Source:
HPRD (in vitro)

		FSHB	CGA
Description		follicle stimulating hormone subunit beta	glycoprotein hormones, alpha polypeptide
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Follicle-stimulating Hormone Complex	Extracellular Region Extracellular Space Golgi Lumen Follicle-stimulating Hormone Complex Pituitary Gonadotropin Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Follicle-stimulating Hormone Activity	Hormone Activity Protein Binding Follicle-stimulating Hormone Activity
	Biological Process	Ovarian Follicle Development Progesterone Biosynthetic Process Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Spermatogenesis Female Gamete Generation Female Pregnancy Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cell Migration Follicle-stimulating Hormone Signaling Pathway Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Sertoli Cell Proliferation	Thyroid Hormone Generation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Gonad Development Hormone-mediated Signaling Pathway Regulation Of Signaling Receptor Activity Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cell Migration Thyroid Gland Development Luteinizing Hormone Secretion Cellular Response To Hormone Stimulus Organ Growth Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Organ Growth Follicle-stimulating Hormone Secretion Developmental Growth
Pathways		Glycoprotein hormones Hormone ligand-binding receptors G alpha (s) signalling events	Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Thyroxine biosynthesis Hormone ligand-binding receptors G alpha (s) signalling events TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases
GWAS		Body mass index ( 25673413) Endometriosis ( 28537267) Endometriosis or migraine ( 32121467) Length of menstrual cycle ( 30202859 26732621) Luteinizing hormone levels in polycystic ovary syndrome ( 26284813) Menarche (age at onset) ( 25231870 27182965) Menopause (age at onset) ( 26414677) Metabolite levels ( 23823483) Number of twin births ( 30760885) Polycystic ovary syndrome ( 26416764 26284813 30566500) Polycystic ovary syndrome (adjusted for age) ( 34791234) Polycystic ovary syndrome (indeterminate subtype) ( 32574161) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Refractive error ( 32231278) Sex hormone levels ( 26014426) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spontaneous dizygotic twinning ( 27132594) Urate levels ( 31578528) Uterine fibroids ( 31649266)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Atrial fibrillation ( 29892015 30061737) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		3 interacting genes: CGA CGB3 FSHR	9 interacting genes: CGB3 CGB5 FSHB FSHR LHB LHCGR PTN PTPN12 TSHB
Entrez ID		2488	1081
HPRD ID		00644	00342
Ensembl ID		ENSG00000131808	ENSG00000135346
Uniprot IDs		A0A0F7RQE8 P01225	A0A087WYZ4 P01215 Q6I9S8
PDB IDs		1FL7 1XWD 4AY9 4MQW 8I2G	1DZ7 1E9J 1FL7 1HCN 1HD4 1HRP 1QFW 1XWD 4AY9 4MQW 7FIG 7FIH 7FII 7T9I 7UTZ 7XW5 8I2G
Enriched GO Terms of Interacting Partners?		Pituitary Gonadotropin Complex Follicle-stimulating Hormone Signaling Pathway Hormone-mediated Signaling Pathway Ovulation Cycle Process Female Gamete Generation G Protein-coupled Receptor Signaling Pathway Hormone Activity Gonad Development Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Follicle-stimulating Hormone Complex Primary Ovarian Follicle Growth Reproductive Structure Development Reproductive Process Rhythmic Process Luteinizing Hormone Secretion Gonadotropin Secretion Sertoli Cell Proliferation Cellular Response To Hormone Stimulus Intracellular Water Homeostasis Regulation Of Protein Kinase A Signaling Developmental Growth Protein-hormone Receptor Activity Cellular Response To Follicle-stimulating Hormone Stimulus Thyroid Hormone Generation Regulation Of Hormone Levels Gamete Generation Response To Follicle-stimulating Hormone Negative Regulation Of Bone Resorption Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Sertoli Cell Development Negative Regulation Of Bone Remodeling Transcytosis Sperm DNA Condensation Cellular Response To Gonadotropin Stimulus Thyroid Hormone Metabolic Process Response To Hormone Uterus Development Female Gonad Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Gonadotropin Thyroid Gland Development Regulation Of Signaling Receptor Activity Positive Regulation Of Steroid Biosynthetic Process Negative Regulation Of Organ Growth Cell Volume Homeostasis Peptide Hormone Binding Regulation Of Hormone Metabolic Process	Female Gamete Generation Hormone Activity Hormone-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway Pituitary Gonadotropin Complex Follicle-stimulating Hormone Signaling Pathway Ovulation Cycle Process Ovarian Follicle Development Progesterone Biosynthetic Process Gamete Generation Sertoli Cell Proliferation Rhythmic Process Protein-hormone Receptor Activity C21-steroid Hormone Biosynthetic Process Reproductive Process Progesterone Metabolic Process Male Gonad Development Signaling Receptor Binding Developmental Process Involved In Reproduction Gonad Development Cellular Response To Gonadotropin Stimulus Uterus Development C21-steroid Hormone Metabolic Process Female Gonad Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Steroid Hormone Biosynthetic Process Response To Gonadotropin Regulation Of Hormone Levels Reproductive Structure Development Ketone Biosynthetic Process Regulation Of Hormone Metabolic Process Hormone Biosynthetic Process Regulation Of Bone Resorption G Protein-coupled Peptide Receptor Activity Regulation Of Bone Remodeling Tissue Regeneration Extracellular Space Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Regulation Of Osteoclast Differentiation Regulation Of Tissue Remodeling Regulation Of Steroid Biosynthetic Process Developmental Growth Steroid Biosynthetic Process Ketone Metabolic Process Follicle-stimulating Hormone Activity Follicle-stimulating Hormone Complex
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