PLA2G15 and EDC4

		PLA2G15	EDC4
Description		phospholipase A2 group XV	enhancer of mRNA decapping 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Lysosome Membrane Extracellular Exosome	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Phospholipid Binding Zinc Ion Binding O-acyltransferase Activity Phospholipase A1 Activity Acylglycerol O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Calcium-independent Phospholipase A2 Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Diacylglycerol Biosynthetic Process Phosphatidylserine Metabolic Process Ceramide Metabolic Process Fatty Acid Catabolic Process Lipid Catabolic Process Phosphatidylcholine Catabolic Process Phosphatidylethanolamine Catabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Hydrolysis of LPC	mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Eosinophil count ( 27863252) Eosinophil percentage of white cells ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum metabolite levels ( 33031748) Waist circumference adjusted for body mass index ( 34021172)	HDL cholesterol ( 21347282) Metabolic syndrome ( 22399527) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		2 interacting genes: IMMT RNF7	42 interacting genes: CCL5 CDC42 CEBPA EIF2AK2 FBLN1 FXR1 FXR2 GIT2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-2 MIR141 MIR15B MIR199A1 MIR200A MIR200B MIR200C MIR205 MIR20A MIR21 MIR214 MIR222 MIR29C MIR34A MIR34C MIR363 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E SNCA SUMO2 YTHDC1
Entrez ID		23659	23644
HPRD ID		07128	06911
Ensembl ID		ENSG00000103066	ENSG00000038358
Uniprot IDs		B4DJW4 Q8NCC3	A0A8B0RAT7 Q6P2E9
PDB IDs		4X90 4X91 4X92 4X93 4X94 4X95 4X97 6MTW
Enriched GO Terms of Interacting Partners?			MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Signal Transduction Extracellular Space Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Angiogenesis Regulation Of Protein Metabolic Process Negative Regulation Of Vasculature Development Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Catabolic Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Population Proliferation Regulation Of Vasculature Development
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