DNAAF11 and ST3GAL1

Data Source: HiPPIP (Novel)

		DNAAF11	ST3GAL1
Name		dynein axonemal assembly factor 11	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cilium Motile Cilium Cell Projection Apical Cytoplasm Dynein Axonemal Particle	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane Trans-Golgi Network Membrane Extracellular Exosome Golgi Medial Cisterna Membrane Golgi Trans Cisterna Membrane
	Molecular Function	Protein Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Male Gonad Development Flagellated Sperm Motility Outer Dynein Arm Assembly Inner Dynein Arm Assembly Motile Cilium Assembly Establishment Of Localization In Cell Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Reproductive System Development Protein Localization To Cilium Axonemal Dynein Complex Assembly Cerebrospinal Fluid Circulation Protein Localization To Motile Cilium	Memory B Cell Differentiation N-acetylneuraminate Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Lipid Metabolic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing Protein Modification Process Sialylation Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Protein Sialylation
Pathways		None	Keratan sulfate biosynthesis Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis
GWAS		No GWAS studies recorded	Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Frontal fibrosing alopecia ( 30850646 ) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Intraocular pressure ( 24002674 ) Personality dimensions ( 23903073 ) Problematic alcohol use in trauma-exposed individuals ( 29082582 ) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447 ) Schizophrenia (negative symptoms) ( 23382809 ) Squamous cell carcinoma ( 26908436 )
Interacting Genes		10 interacting genes: DDX6 LRCH3 LSM2 MEOX2 PLEKHF2 PODN SSX7 TERF1 TSC22D2 TTC23L	1 interacting genes: GSTA1
Entrez ID		23639	6482
HPRD ID		10286	06219
Ensembl ID		ENSG00000129295	ENSG00000008513
Uniprot IDs		Q86X45	Q11201
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Concave Side Of Sperm Head Viral RNA Genome Packaging Golgi Medial Cisterna Membrane Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Protein Sialylation Golgi Trans Cisterna Membrane Memory B Cell Differentiation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Shelterin Complex Assembly P-body Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase Somite Specification Ganglioside Biosynthetic Process Via Lactosylceramide Lsm1-7-Pat1 Complex Septin Cytoskeleton Organization Viral Process Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Outer Dense Fiber Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding Lsm2-8 Complex	Glutathione Derivative Biosynthetic Process Steroid Delta-isomerase Activity Apical Cytoplasm Protein Localization To Motile Cilium Glutathione Peroxidase Activity Linoleic Acid Metabolic Process Dynein Axonemal Particle Outer Dynein Arm Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Inner Dynein Arm Assembly Cerebrospinal Fluid Circulation Reproductive System Development Glutathione Transferase Activity Peroxidase Activity Fatty Acid Binding Prostanoid Metabolic Process Prostaglandin Metabolic Process Axonemal Dynein Complex Assembly Motile Cilium Assembly Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Glutathione Metabolic Process Protein Localization To Cilium Cellular Oxidant Detoxification Sulfur Compound Biosynthetic Process Xenobiotic Metabolic Process Cellular Detoxification Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Male Gonad Development Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Olefinic Compound Metabolic Process Gonad Development Isomerase Activity Modified Amino Acid Metabolic Process Cilium Movement