KLHDC2 and MIS12

		KLHDC2	MIS12
Description		kelch domain containing 2	MIS12 kinetochore complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Membrane	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: EZH2 NEDD8 RBX1 RIC8B SELENOK SELENOS STRN4 USP1	9 interacting genes: CBX3 CBX5 DSN1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		23588	79003
HPRD ID		08824	12379
Ensembl ID		ENSG00000165516	ENSG00000167842
Uniprot IDs		Q9Y2U9	A8K1M4 Q9H081
PDB IDs		6DO3 6DO4 6DO5 8EBL 8EBM 8EBN 8PIF 8SGE 8SGF 8SH2 8UXS 9BC9 9BCA 9BCC	5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Response To Oxidative Stress Protein Modification Process Hepatocyte Homeostasis Cellular Response To Stress Cellular Response To Oxidative Stress Protein Neddylation Positive Regulation Of Error-prone Translesion Synthesis Cell Redox Homeostasis Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Subcompartment Cellular Response To Chemical Stress	Outer Kinetochore Chromosome, Centromeric Region Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Skeletal Muscle Cell Proliferation Nuclear Chromosome Segregation Chromosome Cell Division Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Nuclear Body Muscle Cell Proliferation Regulation Of Meiosis I Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Nucleus Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Kinetochore Organization Positive Regulation Of Cell Cycle Checkpoint Nucleoplasm Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Pole Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Pericentric Heterochromatin Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Nuclear Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Site Of DNA Damage Regulation Of Chromosome Organization Heterochromatin Positive Regulation Of Cell Cycle Process Regulation Of TRNA Methylation Kinetochore Adaptor Activity Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Meiotic Cell Cycle
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