KLHDC2 and SELENOK

Number of citations of the paper that reports this interaction (PubMedID 36805027)
68

Data Source:
BioGRID (unspecified method, enzymatic study, unspecified method)

		KLHDC2	SELENOK
Description		kelch domain containing 2	selenoprotein K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Positive Regulation Of Defense Response To Virus By Host Monoatomic Ion Transport Calcium Ion Transport Response To Oxidative Stress Macrophage Derived Foam Cell Differentiation Protein Palmitoylation Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Positive Regulation Of T Cell Proliferation Respiratory Burst After Phagocytosis Regulation Of Calcium-mediated Signaling Regulation Of Protein Transport Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Monocyte Chemotactic Protein-1 Production T Cell Migration Positive Regulation Of Neutrophil Migration Neutrophil Migration Positive Regulation Of T Cell Migration
Pathways
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: EZH2 NEDD8 RBX1 RIC8B SELENOK SELENOS STRN4 USP1	42 interacting genes: AMIGO1 AQP6 BIK C6orf47 CLN8 CNR2 COMT CPLX4 CREB3 ERBB2 ERBB3 ERBB4 ERGIC3 FAM209A FFAR2 FKBP7 GLP1R GORAB GPR35 GPX8 IL10RA KLHDC2 LMNA MFSD6 MMD MRM1 MTIF3 MUC1 REEP4 RNF19B SAR1A SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35E3 SLC35H1 STMN4 STOM TMEM31 TMPRSS2 TMX2
Entrez ID		23588	58515
HPRD ID		08824	07448
Ensembl ID		ENSG00000165516	ENSG00000113811
Uniprot IDs		Q9Y2U9	Q9Y6D0
PDB IDs		6DO3 6DO4 6DO5 8EBL 8EBM 8EBN 8PIF 8SGE 8SGF 8SH2 8UXS 9BC9 9BCA 9BCC	6DO3
Enriched GO Terms of Interacting Partners?		Response To Oxidative Stress Protein Modification Process Hepatocyte Homeostasis Cellular Response To Stress Cellular Response To Oxidative Stress Protein Neddylation Positive Regulation Of Error-prone Translesion Synthesis Cell Redox Homeostasis Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Subcompartment Cellular Response To Chemical Stress	Membrane ERBB3:ERBB2 Complex Neuregulin Receptor Activity ERBB2 Signaling Pathway ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Bile Acid:sodium Symporter Activity Norepinephrine Transport ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway
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