ARHGAP45 and TRIM50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGAP45	TRIM50
Description		Rho GTPase activating protein 45	tripartite motif containing 50
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Secretory Granule Lumen Azurophil Granule Lumen Cell Projection	Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction	Innate Immune Response
Pathways		Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		9 interacting genes: BICD2 GMIP GOLGA2 HSF2BP PIBF1 PPP1R13B RINT1 TRIM50 ZUP1	39 interacting genes: ARHGAP45 CDK18 CLK2 EFHC2 EPM2AIP1 FAM221B GCC1 HDAC6 IQUB KLHL2 L3MBTL2 LNX1 MEOX2 PIAS2 PLA2G6 RAD23A RSPH14 SPG21 SRC TEPSIN TRAF2 TRIM27 TSGA10IP TSSK3 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBTD1 USP2 XAF1 ZNF438 ZNF620
Entrez ID		23526	135892
HPRD ID		03097	15566
Ensembl ID		ENSG00000180448	ENSG00000146755
Uniprot IDs		B3KVA9 B3KXW7 F5H1R4 K7ES92 K7ES98 Q8IYN3 Q92619	B7ZLG2 Q86XT4
PDB IDs		3D25 3FT3
Enriched GO Terms of Interacting Partners?			Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein K63-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Catabolic Process TORC1 Signaling ISG15 Transferase Activity TOR Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Nucleotide Binding ISG15-protein Conjugation Protein Binding Ubiquitin Protein Ligase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Protein Destabilization Radial Spoke Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Negative Regulation Of TORC1 Signaling Protein Autoubiquitination Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Collateral Sprouting ERBB Signaling Pathway Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Metabolic Process
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