R3HDM1 and PRMT2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		R3HDM1	PRMT2
Description		R3H domain containing 1	protein arginine methyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Transcription Coactivator Activity Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Nuclear Estrogen Receptor Binding Nuclear Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding Histone H3R8 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process		Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Developmental Cell Growth Negative Regulation Of Inflammatory Response Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Chronotype ( 30696823) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Height ( 31562340) Mosquito bite size ( 28199695) Neutrophil count ( 31080455) Red cell distribution width ( 32888494)	Diverticular disease ( 30177863)
Interacting Genes		4 interacting genes: ATXN1 F2RL1 HOXA1 PRMT2	37 interacting genes: BAG6 CBLB CHEK2 CPSF7 DAZAP1 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 IQSEC2 KDM6B MYO6 NCOA1 NCOA6 PGR PRMT8 PRRC2A PSMB3 R3HDM1 RB1 RBM12 RBM22 RIPK2 RXRA SHANK1 SHANK3 SHTN1 SPAG8 THRB WASL WBP11 YLPM1 ZFP36 ZNF341 ZSWIM8
Entrez ID		23518	3275
HPRD ID		10180	09060
Ensembl ID		ENSG00000048991	ENSG00000160310
Uniprot IDs		A0A804HIA8 Q15032	A0A0S2Z3N3 P55345
PDB IDs			1X2P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Renin Secretion Into Blood Stream Visual Behavior Semicircular Canal Formation Histone H3R8 Methyltransferase Activity Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Macromolecule Biosynthetic Process Abducens Nerve Formation Optokinetic Behavior Nuclear Progesterone Receptor Binding Positive Regulation Of Glomerular Filtration Positive Regulation Of Biosynthetic Process Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Killing Of Cells Of Another Organism POZ Domain Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Response To Light Stimulus Cognition Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Protein-arginine N-methyltransferase Activity Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process System Process Regulation Of Glomerular Filtration Peroxisome Proliferator Activated Receptor Binding Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Signaling	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Nucleus Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process MRNA Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Estrogen Response Element Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Dendritic Spine Morphogenesis Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Synaptic Receptor Adaptor Activity Regulation Of Transcription By RNA Polymerase II Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Dendritic Spine Organization RNA Binding Nuclear Estrogen Receptor Binding Neuron Projection Organization Postsynapse Organization Regulation Of Female Receptivity Female Mating Behavior MRNA Transcription By RNA Polymerase II
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