TNFRSF13B and B9D1

		TNFRSF13B	B9D1
Description		TNF receptor superfamily member 13B	B9 domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Ciliary Transition Zone MKS Complex Ciliary Basal Body Cell Projection
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Hedgehog Receptor Activity
	Biological Process	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation	In Utero Embryonic Development Vasculature Development Smoothened Signaling Pathway Cell Projection Organization Regulation Of Protein Localization Embryonic Digit Morphogenesis Camera-type Eye Development Cilium Assembly Neuroepithelial Cell Differentiation
Pathways		TNFs bind their physiological receptors	Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Diabetic retinopathy ( 21441570) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple myeloma ( 32569378 33875642 23955597 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Serum albumin levels ( 29403010) Serum total protein levels ( 23022100 29403010) Sodium levels ( 29403010) Systemic lupus erythematosus ( 33272962) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6	2 interacting genes: EXOSC10 LIG4
Entrez ID		23495	27077
HPRD ID		05365	16866
Ensembl ID		ENSG00000240505	ENSG00000108641
Uniprot IDs		O14836 Q4ACX1	A0A0B4J223 A0A2R8Y646 A0A6Q8PFJ7 A8MYG7 B4DEW0 J3QKN6 Q9UPM9
PDB IDs		1XU1 1XUT
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding CD40 Receptor Complex CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Lymphocyte Homeostasis Leukocyte Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Regulation Of Immunoglobulin Production Thioesterase Binding Positive Regulation Of JUN Kinase Activity Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Multicellular Organismal-level Homeostasis Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Homeostasis Of Number Of Cells B Cell Homeostasis Protein Insertion Into ER Membrane Positive Regulation Of T Cell Cytokine Production Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Lymphocyte Mediated Immunity Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-2 Production Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Immune Response Regulation Of T Cell Cytokine Production Regulation Of Mononuclear Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Immune Effector Process Regulation Of Leukocyte Proliferation Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Signal Transduction	Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity Hematopoietic Progenitor Cell Differentiation DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of RNA Splicing Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Histone H2B Deubiquitinase Activity Negative Regulation Of ARF Protein Signal Transduction Structural Constituent Of Postsynaptic Specialization Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Regulation Of Chromosome Organization Nonhomologous End Joining Complex Nucleotide-excision Repair, DNA Gap Filling Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone H2A Deubiquitinase Activity Intramembranous Ossification Positive Regulation Of Microtubule Nucleation Motor Learning Positive Regulation Of Receptor Catabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Lymphoid Progenitor Cell Differentiation Single Strand Break Repair AMP Binding Regulation Of Organelle Organization TRNA Decay RRNA 3'-end Processing Nuclear MRNA Surveillance Regulation Of Telomerase RNA Localization To Cajal Body Nucleolar Exosome (RNase Complex) Histone H4 Acetyltransferase Activity Maintenance Of Postsynaptic Specialization Structure
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