SMCHD1 and TYMS

		SMCHD1	TYMS
Description		structural maintenance of chromosomes flexible hinge domain containing 1	thymidylate synthetase
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Barr Body Nucleoplasm Chromosome Nuclear Body Site Of Double-strand Break	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	DNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Homodimerization Activity	MRNA Regulatory Element Binding Translation Repressor Activity Thymidylate Synthase Activity Folic Acid Binding Methyltransferase Activity Transferase Activity Transferase Activity, Transferring One-carbon Groups Sequence-specific MRNA Binding
	Biological Process	DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Dosage Compensation By Inactivation Of X Chromosome Nose Development Positive Regulation Of DNA Repair Chromosome Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	DTMP Biosynthetic Process DTTP Biosynthetic Process Nucleotide Biosynthetic Process Negative Regulation Of Translation Methylation Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process DNA Biosynthetic Process
Pathways			Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription
Drugs			Raltitrexed Floxuridine Trifluridine Gemcitabine Fluorouracil Methotrexate Pemetrexed Capecitabine Thymidine monophosphate 10-Propargyl-5,8-Dideazafolic Acid Deoxyuridine monophosphate S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 2,4-Diamino-5-phenyl-6-ethylpyrimidine N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE Tegafur Tegafur-uracil
Diseases
GWAS		Trunk fat mass ( 28552196)	Leukocyte telomere length ( 31171785 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		6 interacting genes: BARD1 CEBPA PEG10 PTEN SRPK2 SUMO2	3 interacting genes: CDC42 SH3GL2 UPF2
Entrez ID		23347	7298
HPRD ID		19413	01774
Ensembl ID		ENSG00000101596	ENSG00000176890
Uniprot IDs		A6NHR9	P04818 Q53Y97
PDB IDs		6MW7	1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E 6ZXO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of MRNA 3'-end Processing Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Negative Regulation Of Synaptic Vesicle Clustering Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2AK127 Ubiquitin Ligase Activity Kinase Binding Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Regulation Of MRNA Processing CHOP-C/EBP Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Vesicle-mediated Intercellular Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process BRCA1-B Complex Regulation Of Osteoblast Differentiation White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Nuclear Speck Organization DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process DTTP Biosynthetic Process RNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Hematopoietic Stem Cell Proliferation	Membrane Organization
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