SMCHD1 and PEG10

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SMCHD1	PEG10
Description		structural maintenance of chromosomes flexible hinge domain containing 1	paternally expressed 10
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Barr Body Nucleoplasm Chromosome Nuclear Body Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Vesicle
	Molecular Function	DNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Homodimerization Activity	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Dosage Compensation By Inactivation Of X Chromosome Nose Development Positive Regulation Of DNA Repair Chromosome Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA Transport Protein Homooligomerization Viral Translational Frameshifting Vesicle-mediated Intercellular Transport
Pathways
Drugs
Diseases
GWAS		Trunk fat mass ( 28552196)
Interacting Genes		6 interacting genes: BARD1 CEBPA PEG10 PTEN SRPK2 SUMO2	21 interacting genes: CALCOCO2 CLIP4 EXOSC5 LAMTOR5 LNX2 MAPT NXF1 RAB3IP RBFOX2 RNF181 RTL8A RTL8B SIAH1 SIAH2 SMCHD1 SNRPA SNW1 TOLLIP UBC VPS26C ZNF512B
Entrez ID		23347	23089
HPRD ID		19413	15117
Ensembl ID		ENSG00000101596	ENSG00000242265
Uniprot IDs		A6NHR9	A0A087WZG9 Q86TG7
PDB IDs		6MW7	7LGA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of MRNA 3'-end Processing Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Negative Regulation Of Synaptic Vesicle Clustering Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2AK127 Ubiquitin Ligase Activity Kinase Binding Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Regulation Of MRNA Processing CHOP-C/EBP Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Vesicle-mediated Intercellular Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process BRCA1-B Complex Regulation Of Osteoblast Differentiation White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Nuclear Speck Organization DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process DTTP Biosynthetic Process RNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Hematopoietic Stem Cell Proliferation	Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding
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