PEG10 and SMCHD1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PEG10	SMCHD1
Description		paternally expressed 10	structural maintenance of chromosomes flexible hinge domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Vesicle	Chromosome, Telomeric Region Barr Body Nucleoplasm Chromosome Nuclear Body Site Of Double-strand Break
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Homodimerization Activity
	Biological Process	Apoptotic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA Transport Protein Homooligomerization Viral Translational Frameshifting Vesicle-mediated Intercellular Transport	DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Dosage Compensation By Inactivation Of X Chromosome Nose Development Positive Regulation Of DNA Repair Chromosome Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS			Trunk fat mass ( 28552196)
Interacting Genes		21 interacting genes: CALCOCO2 CLIP4 EXOSC5 LAMTOR5 LNX2 MAPT NXF1 RAB3IP RBFOX2 RNF181 RTL8A RTL8B SIAH1 SIAH2 SMCHD1 SNRPA SNW1 TOLLIP UBC VPS26C ZNF512B	6 interacting genes: BARD1 CEBPA PEG10 PTEN SRPK2 SUMO2
Entrez ID		23089	23347
HPRD ID		15117	19413
Ensembl ID		ENSG00000242265	ENSG00000101596
Uniprot IDs		A0A087WZG9 Q86TG7	A6NHR9
PDB IDs		7LGA	6MW7
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding	Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of MRNA 3'-end Processing Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Negative Regulation Of Synaptic Vesicle Clustering Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2AK127 Ubiquitin Ligase Activity Kinase Binding Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity PML Body Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Regulation Of MRNA Processing CHOP-C/EBP Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Vesicle-mediated Intercellular Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process BRCA1-B Complex Regulation Of Osteoblast Differentiation White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Nuclear Speck Organization DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process DTTP Biosynthetic Process RNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Hematopoietic Stem Cell Proliferation
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