VPS39 and RTF1

		VPS39	RTF1
Description		VPS39 subunit of HOPS complex	RTF1 homolog, Paf1/RNA polymerase II complex component
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane Lysosomal HOPS Complex	Nucleus Nucleoplasm Nucleolus Cdc73/Paf1 Complex
	Molecular Function	Protein Binding	DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Endocytic Recycling Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Autophagosome-lysosome Fusion Late Endosome To Lysosome Transport	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Blastocyst Growth Chromatin Organization Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance
Pathways		SARS-CoV-2 modulates autophagy	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Asthma ( 32296059) Coronary artery disease ( 29212778) Eosinophil percentage of granulocytes ( 27863252) Height ( 20881960) Itch intensity from mosquito bite ( 28199695) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: HOOK1 MECOM RILP RUNX1 SNW1 STAT3 TFIP11	4 interacting genes: APP SRPK2 TCEA1 UBC
Entrez ID		23339	23168
HPRD ID		10300	11071
Ensembl ID		ENSG00000166887	ENSG00000137815
Uniprot IDs		Q96JC1	Q92541
PDB IDs		6ZE9	2BZE 2DB9 3U1U 4L1P 4L1U 6TED 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Extracellular Matrix Organization Hematopoietic Stem Cell Proliferation Nuclear Speck Early Endosome To Late Endosome Transport Dynein Light Intermediate Chain Binding Negative Regulation Of DNA-templated Transcription Protein Homodimerization Activity Negative Regulation Of RNA Biosynthetic Process Endosome To Lysosome Transport Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Biosynthetic Process Core-binding Factor Complex Negative Regulation Of Transcription By RNA Polymerase II Stem Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Pericentric Heterochromatin Organization CENP-A Recruiting Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Endosome Organization Intralumenal Vesicle Formation Cardiac Muscle Tissue Regeneration Nucleoplasm RNA Sequestering Activity Maintenance Of Cell Number Stem Cell Population Maintenance Lysosomal Transport Positive Regulation Of Vasculature Development Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation DNA-binding Transcription Factor Binding DNA Binding Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Metabolic Process Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3K9me2 Methyltransferase Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lysosomal HOPS Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Nuclear Speck Organization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Presynapse Axon Choice Point Recognition Regulation Of Neuron Apoptotic Process Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion R-loop Processing Endosome Membrane Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding
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