JADE2 and SAR1B

		JADE2	SAR1B
Description		jade family PHD finger 2	secretion associated Ras related GTPase 1B
Image		No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Golgi Cisterna Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Amino Acid Sensor Activity
	Biological Process	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of COPII Vesicle Coating Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Vesicle-mediated Transport Regulation Of Lipid Transport Lipoprotein Transport COPII Vesicle Coating Lipid Homeostasis Membrane Organization COPII-coated Vesicle Cargo Loading Lipid Export From Cell Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		HATs acetylate histones	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Chylomicron assembly SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs			Guanosine-5'-Diphosphate
Diseases			Chylomicron retention disease (CRD); Anderson disease
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Smoking cessation ( 33082346) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: CBX8 CDCA7L CSNK2A1 FBXO7 GAS2L2 GORASP2 H3-4 ING4 PACSIN1 SASH1 TTC3 ZBTB3 ZBTB5 ZNF417 ZNF496	3 interacting genes: CIDEB CREB3 TMEM14B
Entrez ID		23338	51128
HPRD ID		15124	09647
Ensembl ID		ENSG00000043143	ENSG00000152700
Uniprot IDs		A0A087X085 A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1	Q9H029 Q9Y6B6
PDB IDs			8E0A 8E0B 8E0C 8E0D
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Deacetylase Activity Regulation Of Cell Growth Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway CCR1 Chemokine Receptor Binding Induction Of Positive Chemotaxis Release From Viral Latency CAMP Response Element Binding Protein Binding Regulation Of Cell Cycle Positive Regulation Of Positive Chemotaxis Identical Protein Binding Histone H4K5 Acetyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone Acetyltransferase Complex Histone H4K12 Acetyltransferase Activity Execution Phase Of Apoptosis COPI-coated Vesicle Phosphatidic Acid Binding COPII Vesicle Coat Lipid Transfer Activity Lipid Droplet Fusion Protein-lipid Complex Assembly COPII-coated Vesicle Cargo Loading Plasma Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Assembly Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process
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