WDR7 and RAB3GAP1

Number of citations of the paper that reports this interaction (PMID 12786944)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		WDR7	RAB3GAP1
Gene Name		WD repeat domain 7	RAB3 GTPase activating protein subunit 1 (catalytic)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function		Rab GTPase Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation	Brain Development Hypothalamus Development Positive Regulation Of Rab GTPase Activity Lipid Particle Organization Camera-type Eye Development Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Excitatory Postsynaptic Membrane Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization
Pathways
Drugs
Diseases
GWAS		Depression and alcohol dependence ( 22064162) Multiple sclerosis (age of onset) ( 19010793)	Cholesterol, total ( 20686565) Corneal structure ( 21979947)
Protein-Protein Interactions		2 interactors: FRMD6 RAB3GAP1	8 interactors: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7
Entrez ID		23335	22930
HPRD ID		10306	16002
Ensembl ID		ENSG00000091157	ENSG00000115839
Uniprot IDs		Q9Y4E6	B9A6J2 C9J837 Q15042
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Apical Constriction Positive Regulation Of Glutamate Secretion Positive Regulation Of Amino Acid Transport Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Glutamate Secretion Lipid Particle Organization Positive Regulation Of Neurotransmitter Secretion Hypothalamus Development Face Morphogenesis Cellular Protein Localization Head Morphogenesis Actin-mediated Cell Contraction Epithelial Cell Morphogenesis Face Development Regulation Of Neuronal Synaptic Plasticity Body Morphogenesis Actin Filament-based Movement Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Protein Localization Diencephalon Development Limbic System Development Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Synaptic Transmission Membrane Depolarization Cellular Localization Protein Localization To Endoplasmic Reticulum Positive Regulation Of Rab GTPase Activity Anatomical Structure Morphogenesis Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Anion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Ion Transport Epithelial Cell Development Establishment Of Protein Localization To Membrane	Rab Protein Signal Transduction Intracellular Protein Transport Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Transport Ras Protein Signal Transduction Establishment Of Protein Localization Intracellular Transport Protein Localization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Vesicle Size Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Phagosome-lysosome Fusion Transport Phagosome Acidification Negative Regulation Of Macroautophagy Phagolysosome Assembly Establishment Of Mitochondrion Localization Intracellular PH Reduction Axon Guidance PH Reduction
Tagcloud ?			acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle
Tagcloud (Difference) ?			acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle
Tagcloud (Intersection) ?