ACSL6 and HGD

		ACSL6	HGD
Description		acyl-CoA synthetase long chain family member 6	homogentisate 1,2-dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity	Homogentisate 1,2-dioxygenase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neuroblast Proliferation Long-chain Fatty-acyl-CoA Biosynthetic Process	Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tyrosine Metabolic Process L-tyrosine Catabolic Process
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Tyrosine catabolism
Drugs
Diseases			Alkaptonuria
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: PCMTD2 PHYH ZNF655	5 interacting genes: CLDN7 GIT2 NTAQ1 PCDHGC3 TERF1
Entrez ID		23305	3081
HPRD ID		09190	06315
Ensembl ID		ENSG00000164398	ENSG00000113924
Uniprot IDs		A0A494BZW8 A0A494C0B6 A0A494C0J9 A0A499FJL5 B2RB13 B4DFW3 C9J8C7 Q9UKU0	B3KW64 Q93099
PDB IDs			1EY2 1EYB
Enriched GO Terms of Interacting Partners?		Glycine Amidinotransferase Activity Amidinotransferase Activity Homogentisate 1,2-dioxygenase Activity 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity	Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein-N-terminal Asparagine Amidohydrolase Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping Arachidonate-CoA Ligase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Synaptic Vesicle Recycling Long-chain Fatty Acid-CoA Ligase Activity DNA Binding, Bending Regulation Of ARF Protein Signal Transduction Long-chain Fatty-acyl-CoA Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Apicolateral Plasma Membrane Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process
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