ACSL6 and GATM

		ACSL6	GATM
Description		acyl-CoA synthetase long chain family member 6	glycine amidinotransferase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity	Protein Binding Amidinotransferase Activity Glycine Amidinotransferase Activity Transferase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neuroblast Proliferation Long-chain Fatty-acyl-CoA Biosynthetic Process	Creatine Metabolic Process Creatine Biosynthetic Process Learning Or Memory Muscle Atrophy Positive Regulation Of Cold-induced Thermogenesis
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Creatine metabolism
Drugs			Ornithine Glycine Delta-Amino Valeric Acid gamma-Aminobutyric acid Norvaline Alpha-Aminobutyric Acid
Diseases			Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Chronic kidney disease ( 20383146 31152163 26831199) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 30604766 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Homoarginine levels ( 24047826) Phosphatidylcholine-ether levels ( 31551469) Renal function and chronic kidney disease ( 19430482) Serum metabolite levels ( 24625756 33031748) Urinary albumin-to-creatinine ratio ( 31511532) Urinary potassium to creatinine ratio ( 30910378)
Interacting Genes		3 interacting genes: PCMTD2 PHYH ZNF655	2 interacting genes: CYP2E1 LCOR
Entrez ID		23305	2628
HPRD ID		09190	03838
Ensembl ID		ENSG00000164398	ENSG00000171766
Uniprot IDs		A0A494BZW8 A0A494C0B6 A0A494C0J9 A0A499FJL5 B2RB13 B4DFW3 C9J8C7 Q9UKU0	A0A140VK19 P50440
PDB IDs			1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW 9JDW
Enriched GO Terms of Interacting Partners?		Glycine Amidinotransferase Activity Amidinotransferase Activity Homogentisate 1,2-dioxygenase Activity 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity	Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Long-chain Fatty Acid Metabolic Process Benzene Metabolic Process Lipid Hydroxylation Long-chain Fatty Acid Omega-1 Hydroxylase Activity Monoterpenoid Metabolic Process Fatty Acid Metabolic Process Enzyme Binding Arachidonate Epoxygenase Activity Monocarboxylic Acid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Arachidonate-CoA Ligase Activity Lipid Biosynthetic Process Epoxygenase P450 Pathway Long-chain Fatty Acid-CoA Ligase Activity Histone Methyltransferase Binding Long-chain Fatty-acyl-CoA Biosynthetic Process Ubiquitin-specific Protease Binding Benzene-containing Compound Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Hsp90 Protein Binding Arachidonate Metabolic Process Very Long-chain Fatty Acid Metabolic Process Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Neuroblast Proliferation Hsp70 Protein Binding Transcription Corepressor Binding Fatty Acid Derivative Biosynthetic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Lipid Metabolic Process Endoplasmic Reticulum Membrane Monooxygenase Activity Peroxisomal Membrane Fatty Acid Derivative Metabolic Process Phenol-containing Compound Metabolic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neural Precursor Cell Proliferation Icosanoid Metabolic Process
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