NUP210 and TSEN2

		NUP210	TSEN2
Description		nucleoporin 210	tRNA splicing endonuclease subunit 2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol
	Molecular Function	Protein Binding	TRNA-intron Lyase Activity Nucleic Acid Binding Protein Binding Lyase Activity
	Biological Process	Nucleocytoplasmic Transport Protein Transport MRNA Transport	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing TRNA Processing
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	tRNA processing in the nucleus
Drugs
Diseases			Pontocerebellar hypoplasia
GWAS		Coronary artery disease in type 1 diabetes ( 29695241)	A body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Systemic lupus erythematosus ( 28714469) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: CDK1 EXOSC5 MTDH TRIP6	7 interacting genes: CADPS CTAG2 GABPB2 RANBP10 TAX1BP1 TEPSIN TSEN54
Entrez ID		23225	80746
HPRD ID		06368	10576
Ensembl ID		ENSG00000132182	ENSG00000154743
Uniprot IDs		Q8TEM1	A0A7P0T8F8 A0A7P0T914 A0A7P0TA86 C9J7Z4 Q8NCE0
PDB IDs		7R5J 7R5K	7UXA 7ZRZ 8HMY 8HMZ 8ISS
Enriched GO Terms of Interacting Partners?
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