UBXN4 and GNGT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBXN4	GNGT1
Description		UBX domain protein 4	G protein subunit gamma transducin 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Binding	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Response To Unfolded Protein ERAD Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction Intracellular Protein Localization Cardiac Muscle Cell Apoptotic Process Eye Photoreceptor Cell Development Cellular Response To Hypoxia
Pathways			Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823)	Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mosquito bite size ( 28199695) Resting heart rate ( 27798624 29769521) Taxane-induced peripheral neuropathy in breast cancer ( 29278617)
Interacting Genes		5 interacting genes: GNGT1 MAILR TOM1L1 UBQLN1 VCP	14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277
Entrez ID		23190	2792
HPRD ID		18254	01805
Ensembl ID		ENSG00000144224	ENSG00000127928
Uniprot IDs		Q92575	P63211
PDB IDs		2KXJ	7L0P 7L0Q 7L0R 7L0S
Enriched GO Terms of Interacting Partners?		Cellular Response To Oxygen Levels Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Post-translational Protein Modification VCP-NSFL1C Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Arsenite Ion Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Modification-dependent Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Modification Process Macroautophagy Autophagosome Maturation ERAD Pathway Proteolysis Involved In Protein Catabolic Process Proteasome Complex Mitotic Spindle Disassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Modification Process Protein-containing Complex Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Metabolic Process Cytoplasm Protein Quality Control BAT3 Complex Binding Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Deubiquitination Positive Regulation Of Protein Catabolic Process Stress Granule Disassembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Negative Regulation Of Protein Localization To Chromatin Macromolecule Catabolic Process Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Post-translational Protein Modification Deubiquitinase Activator Activity Positive Regulation Of Protein Autophosphorylation Protein-DNA Covalent Cross-linking Repair Derlin-1 Retrotranslocation Complex Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex Regulation Of Protein Localization To Chromatin Response To Hypoxia K48-linked Polyubiquitin Modification-dependent Protein Binding	Heterotrimeric G-protein Complex Signaling Receptor Complex Adaptor Activity G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway GTPase Activity Response To Catecholamine Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus Response To Light Intensity Photoreceptor Disc Membrane Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Sensory Perception GTPase Binding Phototransduction Alpha-N-acetylgalactosaminidase Activity Heterotrimeric G-protein Complex Assembly Rod Bipolar Cell Differentiation GTPase Activator Complex G-protein Gamma-subunit Binding Detection Of Light Stimulus Mu-type Opioid Receptor Binding Photoreceptor Outer Segment Alpha-galactosidase Activity Thermotaxis Dark Adaptation Retina Development In Camera-type Eye Signal Transduction Response To Light Stimulus Sperm Head Plasma Membrane Linear Polyubiquitin Binding Light Adaption Response To Unfolded Protein Protein-containing Complex Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Lysosomal Membrane Photoreceptor Inner Segment Membrane Absorption Of Visible Light Sensory Perception Of Chemical Stimulus Cellular Response To Light Stimulus Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway 11-cis Retinal Binding Detection Of Abiotic Stimulus Nervous System Process
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