ZZEF1 and PTPN4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZZEF1	PTPN4
Gene Name		zinc finger, ZZ-type with EF-hand domain 1	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Calcium Ion Binding Zinc Ion Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process		Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs			Alendronate
Diseases
GWAS
Protein-Protein Interactions		4 interactors: HSPB3 PHYHIP PTPN4 SKIL	11 interactors: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL PRSS1 TK1 ZZEF1
Entrez ID		23140	5775
HPRD ID		15906	01471
Ensembl ID		ENSG00000074755	ENSG00000088179
Uniprot IDs		O43149	P29074
PDB IDs			2CS5 2I75 2VPH 3NFK 3NFL
Enriched GO Terms of Interacting Partners?			Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Response To Organic Substance Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Fetal Process Involved In Parturition Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Postsynaptic Membrane Potential Response To External Stimulus Response To Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Response To Radiation Skeletal Muscle Cell Proliferation Signal Transduction By P53 Class Mediator Membrane Depolarization Chylomicron Remodeling Cellular Response To Hydroxyurea Neuromuscular Process Directional Locomotion Positive Regulation Of Nuclear Cell Cycle DNA Replication Translational Elongation Response To Cortisol Thymidine Metabolic Process Positive Regulation Of Sequestering Of Triglyceride Deoxyribonucleoside Monophosphate Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Triglyceride-rich Lipoprotein Particle Remodeling Cerebellar Granule Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Membrane Potential DNA Damage Response, Signal Transduction Resulting In Transcription Response To Hormone Heterocycle Metabolic Process Prepulse Inhibition Serotonin Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Biosynthetic Process Replication Fork Processing Sleep Positive Regulation Of DNA-dependent DNA Replication Cerebellar Granular Layer Morphogenesis Parturition
Tagcloud ?			abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Difference) ?			abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Intersection) ?