TNRC6B and PAN3

Number of citations of the paper that reports this interaction (PubMedID 21981923)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, proximity labelling technology)

		TNRC6B	PAN3
Description		trinucleotide repeat containing adaptor 6B	poly(A) specific ribonuclease subunit PAN3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol PAN Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleotide Binding RNA Binding Poly(A)-specific Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding Poly(A) Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Processing Protein Targeting Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	Deadenylation of mRNA
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Breast size ( 29855537) Chronotype ( 26955885 30696823) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Hand grip strength ( 25637336) Height ( 19570815) Immature fraction of reticulocytes ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mammographic density (dense area) ( 25342443) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Meat-related diet ( 32066663) Morning person ( 30696823) Neutrophil percentage of white cells ( 27863252) Prostate cancer ( 23065704 19117981) Pulse pressure ( 27618447 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27618447) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Uterine fibroids ( 21460842 31649266 31488892 31249589 30194396) Uterine fibroids (MTAG) ( 31488892)	Bipolar disorder ( 20351715) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Hepcidin/transferrin saturation ratio ( 27846281) Mean corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Pancreatic cancer ( 25086665)
Interacting Genes		4 interacting genes: AGO4 PAN3 RNF10 UBQLN4	5 interacting genes: PABPC1 PAN2 RNF10 SVIL TNRC6B
Entrez ID		23112	255967
HPRD ID		10021	17818
Ensembl ID		ENSG00000100354	ENSG00000152520
Uniprot IDs		Q9UPQ9	Q58A45
PDB IDs
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Catabolic Process MRNA Destabilization RNA Destabilization P-body Positive Regulation Of MRNA Catabolic Process Nuclear Proteasome Complex Positive Regulation Of MRNA Metabolic Process MRNA Catabolic Process PAN Complex Negative Regulation Of Autophagosome Maturation RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability SiRNA-mediated Gene Silencing By MRNA Destabilization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Cytosolic Proteasome Complex Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex Regulation Of Nucleobase-containing Compound Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process K48-linked Polyubiquitin Modification-dependent Protein Binding RISC Complex Assembly Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Catabolic Process Poly(A)-specific Ribonuclease Activity Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Pre-miRNA Processing Regulation Of Autophagosome Maturation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Glial Cell Proliferation MRNA Methylguanosine-cap Decapping Positive Regulation Of Myelination Positive Regulation Of RNA Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Poly(A) Binding RNA Decapping Synaptonemal Complex Assembly MiRNA Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Synaptonemal Complex Organization Positive Regulation Of Catabolic Process	Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process P-body PAN Complex Mitochondrial Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Catabolic Process Nucleic Acid Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Post-transcriptional Regulation Of Gene Expression MCRD-mediated MRNA Stability Complex Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing Microtubule Minus-end RNA Catabolic Process Negative Regulation Of Schwann Cell Proliferation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Adenohypophysis Development CRD-mediated MRNA Stabilization Spinal Cord Association Neuron Differentiation Poly(A)-specific Ribonuclease Activity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Actin Filament Severing Translation Activator Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hypothalamus Development
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